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The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin C arm | Experimental | Intravenous loading of 100mg/kg ascorbic acid before induction, Maximus 10g |
|
| Control arm | Placebo Comparator | Intravenous loading of the same volume Normal saline as experimental arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ascorbic acid 100mg/kg, Maximus 10g | Drug | Intravenous loading of 100mg/kg ascorbic acid with normal saline, totally 100ml Completed before induction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Numeric rating scale for pain | 11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain | 15 minutes postoperatively |
| Numeric rating scale for pain | 11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain | 1 hour postoperatively |
| Numeric rating scale for pain | 11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain | 6 hours postoperatively |
| Numeric rating scale for pain | 11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain | 24 hours postoperatively |
| Numeric rating scale for pain | 11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain | 48 hours postoperatively |
| Numeric rating scale for soreness (Sngception) | 11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness | 15 minutes after surgery |
| Numeric rating scale for soreness (Sngception) | 11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness | 1 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Morphine consumption | Amount of IV morphine consumption postoperatively | 48 hours postoperatively |
| Time to first rescue morphine requirement at post-anesthetic care unit | Duration from arriving post-anesthetic care unit to requiring first morphine injection |
| Measure | Description | Time Frame |
|---|---|---|
| Blood ascorbic acid concentration | Blood ascorbic acid analysis | Preoperative baseline and postoperative day1 |
| PostOP Knee joint range of motion | In degree from zero to 170 |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jen-Yin Chen | Department of Anesthesiology, Chimei Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chi Mei Medical Center | Tainan | Tainan City | 701 | Taiwan |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D001205 | Ascorbic Acid |
| D014002 | Tin Fluorides |
| ID | Term |
|---|---|
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Control Rx | Drug | Intravenous loading 100ml normal saline |
|
| Numeric rating scale for soreness (Sngception) | 11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness | 6 hours postoeratively |
| Numeric rating scale for soreness (Sngception) | 11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness | 24 hours postoperatively |
| Numeric rating scale for soreness (Sngception) | 11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness | 48 hours postoperatively |
| up to 2 hours |
| Severity of postoperative nausea/ vomiting and dizziness | From 0 to 5, 0: non, 1: mild, 2: moderate, 3: severe, 4: unbearable | 48 hours postoperatively |
| 72 hours postoperatively |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D006880 |
| Hydroxy Acids |
| D002241 | Carbohydrates |
| D005459 | Fluorides |
| D006858 | Hydrofluoric Acid |
| D017611 | Fluorine Compounds |
| D007287 | Inorganic Chemicals |
| D017971 | Tin Compounds |
| D002327 | Cariostatic Agents |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |