EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk of Recurrence
EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk of Recurrence
The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study participation could last up to 10 years.
Inclusion Criteria:
Exclusion Criteria:
Irvine, California 92612, United States
Orange, California 92868, United States
Sacramento, California 95817, United States
San Francisco, California 94110, United States
Greeley, Colorado 80631, United States
Milford, Massachusetts 01757, United States
South Weymouth, Massachusetts 02190, United States
Mineola, New York 11501, United States
Philadelphia, Pennsylvania 19107, United States
CABA, C1430EGF, Argentina
Capital, X5008HHW, Argentina
Liège, 4000, Belgium
Rio de Janeiro, 22250-905, Brazil
São José do Rio Preto, 15090000, Brazil
São Paulo, 01317-001, Brazil
São Paulo, 04039-901, Brazil
Montreal, H4J 1C5, Canada
Fuzhou, 350025, China
Wuhan, 430022, China
Bordeaux, 33076, France
Mont-de-Marsan, 40024, France
Athens, 151 23, Greece
Hksar, Hong Kong
Hachioji-shi, 192-0032, Japan
Osaka, 540-0006, Japan
Otashi, 373-8550, Japan
Shinjyuku-ku, 162-8655, Japan
Yahaba-cho, Shiwa-gun, 028-3695, Japan
Mexico City, 03100, Mexico
Warsaw, 02-781, Poland
Lisbon, 1649-035, Portugal
Cheonan-si, 31151, South Korea
Hwasun-gun, 58128, South Korea
Namdong-gu, 21565, South Korea
El Palmar, Murcia, 30120, Spain
Changhua County, 50006, Taiwan
Altindağ, 06230, Turkey (Türkiye)
Istanbul, 34722, Turkey (Türkiye)
Istanbul, Pendik, 34899, Turkey (Türkiye)
Izmir, Karsiyaka, 009035575, Turkey (Türkiye)
Malatya, 44280, Turkey (Türkiye)
Stanbul, 34214, Turkey (Türkiye)
East Kilbride, Glasgow, G75 8RG, United Kingdom