Prospective Study for Neuromelanin Image Analysis

Prospective Data Collect Study for Development of Neurimelanin Image Analysis System

In order to develop an image analysis system that automatically detects and quantifies neuromelanin, this study aims to construct a database of a wide sample by collecting brain MRI neuromelanin images prospectively.

Parkinsin group

Inclusion Criteria:

• Adults over 19 years old
• Those who have clinically shown Parkinson's symptoms such as tremor, Rigidity, Bradykinesa and gait disturbance and are scheduled to take MRI scans
• Dopamine transporter imaging shows a significant decrease in visual dopamine intake
• A person who can read and understand the description and informed consent form
• Upon hearing and fully understanding the detailed explanation of this clinical trial, a person who has voluntarily decided to participate and agreed in writing to comply with the precautions

Exclusion Criteria:

• Patient with a history of claustrophobia and mental illness;
• Patient with metallic substances in the body
• Any female subject who is likely to be pregnant who does not agree to contraception in a medically permitted manner during this clinical trial period
• Pregnant or lactating women
• Other cases where the investigator judged that it is difficult to participate in the study;

Healthy volunteer group

Inclusion Criteria:

• Adults over 19 years old
• A person who has no family history or diagnostic history of movement disorders;
• A person with a score of 8 or higher on the CCSIT(cross cultural smell identification test)
• A person with a score of 27 or higher on the MMSE Test
• No Parkinson's symptoms on a neurological examination
• Upon hearing and fully understanding the detailed explanation of this clinical trial, a person who has voluntarily decided to participate and agreed in writing to comply with the precautions

Exclusion Criteria:

• Patient with a history of central nervous system disease or cognitive disorder
• Patient with a history of claustrophobia and mental illness;
• Patient with metallic substances in the body
• Any female subject who is likely to be pregnant who does not agree to contraception in a medically permitted manner during this clinical trial period
• Pregnant or lactating women
• Other cases where the investigator judged that it is difficult to participate in the study;