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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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Postoperative ileus (POI) after colorectal surgery is frequent and is a burden for national health authority because it increases the morbidity and the length of hospital stay.
Some of the stage of the mechanism of POI are known and are now targeted to reduce its occurence but despite these measures, POI still happens in 10-30% of surgeries.
The role of the intestinal microbiota in POI is unknown while it could be a new target to reduce its duration or its occurence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Ileus | Patients that experience POI after colorectal surgery. POI is defined by the presence of 2 of the 5 criteria of Vather from the first postoperative day. The first 10 consecutive patients experiencing POI will be included in the study. |
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| No POI group | Patients that do not experience POI. The 10 patients having the fastest recovery of gastro-intestinal functions after surgery during the period of inclusion will be included in the study |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Feces collection | Other | Feces will be collected, at home, by the patient., by using a collection kit. The stools are collected in the 2 last days before surgery. After surgery, the first stool is collected, during the hospitalization, by using the same kit. Stools are conserved in the same condition, before being frozen in our local biologic ressources center. |
| Measure | Description | Time Frame |
|---|---|---|
| Composition of the feces microbiota before surgery | The composition of the microbiota will be assessed by the analysis of the region V3 V4 of the 16S rRNA, amplificateur by high flow sequencing | within the 2 last days before surgery |
| Composition of the feces microbiota after surgery | The composition of the microbiota will be assessed by the analysis of the region | up to the first postoperative stools, an average of 3 postoperative days |
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Inclusion Criteria:
Exclusion Criteria:
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10 patients with POI and 10 patients without POI selected in the consecutive patients undergoing colorectal surgery during the period of inclusion.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Angers University Hospital, visceral and endocrine surgery department | Angers | 49000 | France |
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collection of feces before and after surgery
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