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| Name | Class |
|---|---|
| Direction Générale de l'Offre de Soins | OTHER_GOV |
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In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done. The main aims are to estimate the prevalence of NDD among siblings and to evaluate the feasibility and acceptability of a standardized screening procedure.
Although NDD are frequent among siblings of children with ASD, their developmental screening is not yet sufficiently organized in routine practice. The needs and the characteristics of these siblings have yet to be better understood in order to define their developmental surveillance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| neurodevelopmental disorders | Step 1 - Screening: the targeted sample is the siblings of the autistic children, these siblings being at risk of neurodevelopmental disorders. Step 2 - Clinical interview: All the children with a positive screening. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Step 1 - Screening ; Step 2 - Clinical interview | Diagnostic Test | Step 1: screening is performed by online parental questionnaires (SRS-2, Identidys scale, DCDQ, parental concerns questionnaire ) via a web platform. Parents and registered doctors will be informed by mail in case of negative screening; In case of positive screening, they will be called by phone in order to give them the results and to invite them for a clinical and semi-structured interview. Step 2: The semi-structured interview will be performed by a psychologist specialized in NDD in order to clinically confirm the results of the screening and refer the child to care and interventions, by mail to the registered doctor. Around 12 months after this interview, parents will be called by phone to collect a description of the referral and their satisfaction about the screening process. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of family participation | Families' participation rate and, among participants, number of children with a NDD diagnosis at the end of the screening study. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Sensibility, specificity, positive predictive values (PPV) and negative predictive values (NPV) of the screening procedure | 12 months | |
| Percentage of satisfied parents | Estimate the level of satisfaction of parents who participated in the screening with the parental satisfaction score via the Visual Analog Scale (VAS). VAS is a scale from 0 (not at all satisfied) to 100 (very satisfied) |
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Inclusion Criteria:
Exclusion Criteria:
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The expected number of children is 384 children (142 with NDD and 242 without NDD).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cécile MICHELON | Contact | 467330986 | +33 | c-michelon@chu-montpellier.fr |
| Charlotte GERBE | Contact | charlotte.gerbe@chu-montpellier.fr |
| Name | Affiliation | Role |
|---|---|---|
| Véronique GONNIER, Dr | University Hospital, Montpellier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Montpellier | Recruiting | Montpellier | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36717133 | Derived | Baghdadli A, Audras-Torrent L, Rattaz C, Gonnier V, Ferrando L, Michelon C, Odoyer R, Maffre T, Picot MC. Multistage screening process for neurodevelopmental disorders in siblings of children with autism: the FRATSA protocol study. BMJ Open. 2023 Jan 30;13(1):e066520. doi: 10.1136/bmjopen-2022-066520. |
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| ID | Type | URL | Comment |
|---|---|---|---|
| Study Protocol | View IPD |
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| 12 months |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D065886 | Neurodevelopmental Disorders |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D001523 | Mental Disorders |
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