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| Name | Class |
|---|---|
| Ministry of Science and Technology, Taiwan | OTHER_GOV |
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A study of the relation between genetic biomarkers and child language development in Taiwan.
The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child language development and language disorder.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | healthy child | ||
| experimental | patients with language disorder |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The research does not require interventions | Genetic | We use Whole-exome sequence (WES) to analyze if there is any gene mutations for DLD(developmental language disorder) children. |
| Measure | Description | Time Frame |
|---|---|---|
| Scores of cognitive function 1 | Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.) | baseline |
| Scores of cognitive function (2 y/o to 6 y/o) | Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.) | baseline |
| Scores of cognitive function (6 y/o to 16 y/o) | Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.) | baseline |
| Scores of cognitive function 3 | Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.) | baseline |
| Scores of language function 1 | Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.) | baseline |
| Scores of language function 2 | Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.) | baseline |
| Scores of general development | Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.) Applied for children aged 3-71 months. Assessing areas: Cognition, language, motor, social, and self-care skills. Every item is scored 0 or 1, indicating whether the child 'fails' or 'passess' that item. |
| Measure | Description | Time Frame |
|---|---|---|
| Scores of participation(2-5 y/o) | Assessment of Preschool Children's Participation (Scores from 0 to 45, higher scores mean a better outcome.) | baseline |
| Scores of participation(>6 y/o) | Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores mean a better outcome.) |
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Inclusion Criteria:
Exclusion Criteria of Healthy Child:
Inclusion Criteria of Child with language disorder:
Exclusion Criteria of Child with language disorder:
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Control and experimental groups
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| Name | Affiliation | Role |
|---|---|---|
| Chia-Ling Chen, MD, PhD | Chang Gung Memorial Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Gung Memoria Hospital | Taoyuan | Taiwan |
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samples with DNA
| baseline |
| Gene test 1 | Microarray (Use Axiom Genome-Wide TWB 2.0 Array Plate (TWB 2.0) to analyze SNPs of disease-related biomarkers.) | baseline |
| Gene test 2 | Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85, Samtools86, Picard, Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.) | baseline |
| baseline |
| Scores of activities | Functional Independence Measure for Children (Scores from 18 to 126, higher scores mean a better outcome.) | baseline |
| Scores of quality of life | Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.) | baseline |