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Funding stopped
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| Name | Class |
|---|---|
| Center for Man in Aviation, Royal Netherlands Air Force | UNKNOWN |
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SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force. All asymptomatic aircrew (≥40 years) are asked to undergo a coronary CT scan on a voluntary basis, following the exercise electrocardiograms performed at their routine aeromedical examination. Coronary Artery Calcium score (CACS) and CCTA findings are reported.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CT Angiography | Other | Coronary CT Angiography will be performed on all individuals |
|
| Exercise stress test | Other | An bicycle exercise stress test will be performed on all individuals |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CT Angiography | Radiation | A CTA will be performed on asymptomatic individuals |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Determine the prevalence and severity of CAD in asymptomatic air crew using CCTA as a primary screening tool | 8 Years |
| Measure | Description | Time Frame |
|---|---|---|
| Determine the diagnostic accuracy of clinically relevant CAD of the exercise stress test versus CCTA | Both modalities are used to track down clinically relevant CAD. Clinically relevant CAD is defined as a stenosis of >50%. | 8 Years |
| Compare the incidence of Major Adverse Cardiac Events (MACE) and all-cause mortality in populations screened between primary and secondary screening after 12 months |
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Inclusion Criteria:
Exclusion Criteria:
Typical angina
Prior myocardial infarction
Prior revascularization therapy (i.e. percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG))
Left ventricular ejection fraction <35%
Does not comprehend study requirements, and/or is unwilling or unable to comply to study procedures
CT-related contra-indications
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| Name | Affiliation | Role |
|---|---|---|
| Hendrik Nathoe, PhD | UMC Utrecht | Principal Investigator |
| Erik Frijters | UMC Utrecht | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Man in Aviation | Soesterberg | Utrecht | 3769 DE | Netherlands | ||
| Utrecht University Medical Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40550709 | Derived | Frijters E, Nathoe H, Grobben R, Broekhuizen L, Rienks R, Velthuis B. Prevalence and severity of coronary artery disease in asymptomatic military air crew in the Netherlands: a prospective, cross-sectional study (SUSPECT). BMJ Open. 2025 Jun 23;15(6):e100250. doi: 10.1136/bmjopen-2025-100250. |
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Every participant will perform an exercise test and receive a CTA afterwards
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| Exercise stress test |
| Diagnostic Test |
A routine exercise stress test will be performed on a bicycle |
|
| 8 Years |
| Compare the incidence of coronary angiograms and revascularization procedures in the population screened with CTA compared to a historical population using CTA as a secondary screening tool | 8 Years |
| Establish the additive value of coronary artery calcium score (CACS) in addition to clinical risk scores as a predictor of CAD on CCTA | 8 Years |
| Utrecht |
| 3584 CX |
| Netherlands |
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D009784 | Occupational Diseases |
| D004194 | Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
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