A Phase 2 Randomized Clinical Study of MK-4280A (Coformulated Favezelimab [MK-4280] Plus Pembrolizumab [MK-3475]) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (KEYFORM-008)
A Phase 2 Randomized Clinical Study of MK-4280A (Coformulated Favezelimab [MK-4280] Plus Pembrolizumab [MK-3475]) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (KEYFORM-008)
Researchers are looking for a way to treat classical Hodgkin lymphoma (cHL) that is relapsed (the cancer has come back after treatment) or refractory (current treatment has stopped working to slow or stop cancer growth). Researchers want to learn if people who receive coformulated favezelimab/pembrolizumab (MK-4280A) live longer without the cancer getting worse compared to those who receive chemotherapy.
Inclusion Criteria:
Exclusion Criteria:
Tucson, Arizona 85719, United States
Torrance, California 90502, United States
Baltimore, Maryland 21201, United States
Baltimore, Maryland 21231, United States
Grand Rapids, Michigan 49503, United States
Mendoza, M5500AYB, Argentina
St Albans, Victoria 3021, Australia
Namur, 5530, Belgium
Wuhan, Hubei 430010, China
Chengdu, Sichuan 610041, China
Tianjin, Tianjin Municipality 300060, China
Brno, Brno-mesto 625 00, Czechia
Hradec Králové, 500 05, Czechia
Prague, 128 08, Czechia
Rennes, Brittany Region 35033, France
Toulouse, Haute-Garonne 31059, France
Limoges, Haute-Vienne 87042, France
Ulm, Baden-Wurttemberg 89081, Germany
Cologne, North Rhine-Westphalia 50937, Germany
Münster, North Rhine-Westphalia 48149, Germany
Dresden, Saxony 01307, Germany
Krakow, Lesser Poland Voivodeship 31-826, Poland
Wroclaw, Lower Silesian Voivodeship 50-556, Poland
Warsaw, Masovian Voivodeship 02-781, Poland
Gdansk, Pomeranian Voivodeship 80-214, Poland
Kielce, Świętokrzyskie Voivodeship 25-734, Poland
Busan, Pusan-Kwangyokshi 49241, South Korea
Seoul, 03722, South Korea
Las Palmas de Gran Canaria, Las Palmas 35016, Spain
Salamanca, 37007, Spain
Stanbul, Istanbul 34214, Turkey (Türkiye)
Ankara, 06230, Turkey (Türkiye)
Glasgow, Glasgow City G12 0YN, United Kingdom
London, London, City of EC1A 7BE, United Kingdom