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This is a study performed to evaluate the role of vitamin D supplementation on the strength of levator ani muscle in menopausal women with pelvic organ prolapse
Forty eight POP women were divided into experimental and control groups in this quasi-experimental study. The experimental group was given 0.5 mcg alfacalcidol orally for three months. We measured levator ani muscle strength, serum 25-hydroxy-vitamin D3 levels, and serum Vitamin D Receptor (VDR) levels at zero months and three months preoperative. Enzyme-linked immunosorbent assay (ELISA) assessed VDR and myoblast determination protein 1 (MyoD) protein expressions in levator ani muscle surgical biopsies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alfacalcidol | Active Comparator | Alfacalcidol 0.5 mcg orally given for 3 months |
|
| Control | Placebo Comparator | Placebo given orally for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alfacalcidol 0.0005 MG | Drug | Alfacalcidol 0.5 mcg is given orally for 3 months, then vitamin D3 and vitamin D receptor levels are measured |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vitamin D3 levels | Vitamin D3 levels measured using lab tests | 3 months |
| Vitamin D receptor levels | Vitamin D receptor levels as assessed by ELISA | 3 months |
| Levator ani muscle strength | Levator ani muscle strength as measured using anometry | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| RM Sonny Sasotya, Ph.D. | Universitas Padjadjaran | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitas Padjadjaran | Bandung | West Java | 40161 | Indonesia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31039170 | Result | Zhang L, Quan M, Cao ZB. Effect of vitamin D supplementation on upper and lower limb muscle strength and muscle power in athletes: A meta-analysis. PLoS One. 2019 Apr 30;14(4):e0215826. doi: 10.1371/journal.pone.0215826. eCollection 2019. | |
| 33935807 | Result | Latham CM, Brightwell CR, Keeble AR, Munson BD, Thomas NT, Zagzoog AM, Fry CS, Fry JL. Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health. Front Physiol. 2021 Apr 14;12:660498. doi: 10.3389/fphys.2021.660498. eCollection 2021. |
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Anonymised patient data are available upon written request to the authors
until 31 December 2026
Access will be given upon written request to the authorrs
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| ID | Term |
|---|---|
| D056887 | Pelvic Organ Prolapse |
| ID | Term |
|---|---|
| D011391 | Prolapse |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C008088 | alfacalcidol |
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| Placebo | Drug | Placebo drug is given orally for 3 months, then vitamin D3 and vitamin D receptor levels are measured |
|