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This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Postoperative NSAIDs | Other |
| |
| Preemptive analgesia followed by Postoperative NSAIDs | Experimental |
| |
| Postoperative patient-controlled analgesia pump | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preemptive flurbiprofen axetil | Drug | 50mg once，30min before induction anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain score | In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain. | 4 hours after surgery |
| Postoperative pain score | In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain. | 12 hours after surgery |
| Postoperative pain score | In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain. | 24 hours after surgery |
| Postoperative pain score | In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain. | 36 hours after surgery |
| Postoperative pain score | In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain. | 48 hours after surgery |
| Postoperative pain score | In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain. |
| Measure | Description | Time Frame |
|---|---|---|
| Time to first postoperative flatus | Time from the end of surgery to the first flatus. | Up to 14 days after surgery |
| Time to first postoperative defaecation | Time from the end of surgery to the first defaecation. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| zhu zhixiang | Contact | 13311131231 | zhuzhixiang2010@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cancer Hospital Chinese Academy of Medical Sciences | Recruiting | Beijing | China |
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| Postoperative flurbiprofen axetil | Drug | 50mg bid |
|
| Patient-controlled analgesia pump | Device | Sufentanil 2.5 μg/kg+ondansetron 8mg, prepared to 100ml normal saline; background dose: 2 ml/h, single press analgesic pump injection volume: 0.5 ml, locking time: 15 min. |
|
| 60 hours after surgery |
| Postoperative pain score | In the Visual Analog Score to be used as the pain measurement criterion, '0' is the minimum value that indicates no pain, while '10' is the maximum value that defines the most severe pain. | 72 hours after surgery |
| Up to 14 days after surgery |
| Abdominal distension score | Abdominal distension was measured using a scoring system, '0' is the minimum value that indicates no abdominal distension, while '10' is the maximum value that defines the most severe abdominal distension. | 24 hours after surgery |
| Abdominal distension score | Abdominal distension was measured using a scoring system, '0' is the minimum value that indicates no abdominal distension, while '10' is the maximum value that defines the most severe abdominal distension. | 48 hours after surgery |
| Abdominal distension score | Abdominal distension was measured using a scoring system, '0' is the minimum value that indicates no abdominal distension, while '10' is the maximum value that defines the most severe abdominal distension. | 72 hours after surgery |
| Side effects related to opioids | Nausea and vomiting were measured using a scoring system(0 = no nausea, 1 = only nausea, 2 = both nausea and vomiting). | 24 hours after surgery |
| Side effects related to opioids | Nausea and vomiting were measured using a scoring system(0 = no nausea, 1 = only nausea, 2 = both nausea and vomiting). | 48 hours after surgery |
| Side effects related to opioids | Nausea and vomiting were measured using a scoring system(0 = no nausea, 1 = only nausea, 2 = both nausea and vomiting). | 72 hours after surgery |
| Time to first postoperative ambulation | Time from the end of surgery to the first postoperative ambulation | Up to 14 days after surgery |
| Hospital duration from operation to discharge | Time from the end of surgery to discharge from the hospital | Up to 60 days after surgery |
| Rate of pulmonary infection | Rate of pulmonary infection up to 30 days after surgery | Up to 30 days after surgery |
| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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