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The purpose of this study is to investigate the effects of intravenous lidocaine on serum miRNA-135a and its downstream proteins Rock2 and Add1 in elderly patients undergoing non-cardiac under general anesthesia.
Postoperative cognitive dysfunction (POCD) is a major complication following surgeries and anesthesia, especially in elderly individuals. Lidocaine, an inexpensive, widely available, and relatively safe compound, is a local anesthetic that readily crosses the blood-brain barrier. Intravenous lidocaine can reduce the incidence of POCD. However, the mechanism is still unclear.
Rock2 and Add1, which are regulated by miRNA-135a, play a key role in learning, memory, and cognition.
The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD, and the levels of Rock2, Add1, and miRNA-135a in elderly patients undergoing non-cardiac under general anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine | Experimental | Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the first hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery. |
|
| Normal saline | Placebo Comparator | Normal saline administered as a bolus and an infusion with identical volume and rate changes as the treatment group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine | Drug | Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the frst hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes from Baseline miRNA-135A at the end of surgery immediately and 1, 3days after surgery | Venous blood was extracted, and the serum miRNA-135a level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery | at preoperation, at the end of surgery immediately, 1day and 3day after surgery |
| Changes from Baseline Rock2 at the end of surgery immediately and 1, 3days after surgery | Venous blood was extracted, and the serum Rock2 level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery | at preoperation, at the end of surgery immediately, 1day and 3day after surgery |
| Changes from Baseline Add1 at the end of surgery immediately and 1, 3days after surgery | Venous blood was extracted, and the serum Add1 level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery | at preoperation, at the end of surgery immediately, 1day and 3day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Changes from Baseline mini-mental state examination (MMSE) at the end of surgery immediately and 1, 3days after surgery | MMSE was performed | at preoperation,1day and 3day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative cognitive dysfunction (POCD) | the incidence of POCD | at preoperation,1day and 3day after surgery |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hanxiang Ma | Contact | +86-13519591508 | mahanxiang@hotmail.com | |
| Li Zhao | Contact | +86-15595293568 | zhaoli295@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Li Zhao | General Hospital of Ningxia Medical University | Principal Investigator |
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| ID | Term |
|---|---|
| D000079690 | Postoperative Cognitive Complications |
| D009477 | Hereditary Sensory and Autonomic Neuropathies |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D060825 | Cognitive Dysfunction |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| Normal saline | Drug | Patients are received equal volumes of saline intravenously until the end of the surgery |
|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D009421 | Nervous System Malformations |
| D009422 | Nervous System Diseases |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D011115 | Polyneuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| Aniline Compounds |
| D000588 | Amines |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |