| Primary | 28-days Mortality Rate | | | Posted | | Count of Participants | | Participants | | 28 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| | | Title | Denominators | Categories |
|---|
| | | Title | Measurements |
|---|
| dead | | | alive | |
|
| | Group IDs | Group Description | Statistical Method | Statistical Comment | P-Value | P-Value Comment | Parameter Type | Parameter Value | Dispersion Type | Dispersion Value | Confidence Interval Sides | Confidence Interval % | CI Lower Limit | CI Upper Limit | CI Lower Limit Comment | CI Upper Limit Comment | Estimate Comment | Tested Non-Inferiority | Non-Inferiority Type | Non-Inferiority Comment | Other Analysis Description |
|---|
| | Kruskal-Wallis | | <0.001 | | | | | | | | | | | | | | Superiority | | | | | Kruskal-Wallis | | 0.176 | |
|
| Primary | Number of Participants With Positive or Negative Polymerase Chain Reaction (PCR) Test Results at End of Hospital Visit | | | Posted | | Count of Participants | | Participants | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Primary | Number of Participants With Infusion Related Reactions, Hypersensitivity Reactions and Any Serious Adverse Events | | | Posted | | Count of Participants | | Participants | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Need for Invasive Mechanical Ventilation | | | Posted | | Count of Participants | | Participants | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Oxygen Support Duration (Days) | | | Posted | | Mean | Standard Deviation | days | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Time to Clinical Improvement (Defined as 2 Points Reduction in the WHO Disease Ordinal Progression Scale or Discharge, Whatever Happens First | in days WHO disease ordinal progression scale 0= Uninfected Ambulatory mild disease
- Asymptomatic; viral RNA detected
- Symptomatic; independent.
- Symptomatic; assistance needed Hospitalized: moderate disease
- Hospitalized; no oxygen therapy
- Hospitalized; oxygen by mask or nasal prongs Hospitalized: sever disease
- Hospitalized; oxygen by NIV or high flow
- Intubation and mechanical ventilation, pO2 /FIO2 ≥ 150 or Spo2 /FiO2 ≥200
- Mechanical ventilation pO2/FiO2 <150 (SpO2 /FiO2 < 200) or vasopressors
- Mechanical ventilation pO2 / FiO2 < 150 and vasopressors, dialysis or ECMO Dead
- Dead
| | Posted | | Mean | Standard Deviation | days | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | |
|
| Secondary | Duration of Hospitalization | | | Posted | | Mean | Standard Deviation | days | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Sequential Organ Function Assessment (SOFA) Score on Day 3 | minimum 0 to maximum 24, higher scores mean worse outcomes Platelets, ×10³/µL ≥150 0 100-149+1 50-99+2 20-49+3 <20+4 Glasgow Coma Scale If on sedatives, estimate assumed GCS off sedatives 15 0 13-14+1 10-12+2 6-9+3 <6+4 Bilirubin, mg/dL (μmol/L) <1.2 (<20) 0 1.2-1.9 (20-32)+1 2.0-5.9 (33-101)+2 6.0-11.9 (102-204)+3 ≥12.0 (>204)+4 Mean arterial pressure OR administration of vasoactive agents required Listed doses are in units of mcg/kg/min No hypotension 0 MAP <70 mmHg+1 DOPamine ≤5 or DOBUTamine (any dose)+2 DOPamine >5, EPINEPHrine ≤0.1, or norEPINEPHrine ≤0.1+3 DOPamine >15, EPINEPHrine >0.1, or norEPINEPHrine >0.1+4 Creatinine, mg/dL (μmol/L) (or urine output) <1.2 (<110) 0 1.2-1.9 (110-170)+1 2.0-3.4 (171-299)+2 3.5-4.9 (300-440) or UOP <500 mL/day+3 ≥5.0 (>440) or UOP <200 mL/day+4 | | Posted | | Count of Participants | | Participants | | Day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug |
|
| Secondary | COVID-19 World Health Organization (WHO) Disease Progression Scale at Day 3 | minimum 0 to maximum 10, higher scores mean worse outcomes | | Posted | | Count of Participants | | Participants | | Day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Aspartate Aminotransferase (AST) at Day 3 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Ferritin at Day 3 | | | Posted | | Mean | Standard Deviation | micrograms per liter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Lactate Dehydrogenase (LDH) at Day 3 | | | Posted | | Mean | Standard Deviation | international units per liter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | D-dimer at Day 3 | | | Posted | | Mean | Standard Deviation | μg/mL | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Alanine Aminotransferase (ALT) at Day 3 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Albumin at Day 3 | | | Posted | | Mean | Standard Deviation | gm/dl | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Bilirubin at Day 3 | | | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | C-reactive Protein (CRP) at Day 3 | | | Posted | | Mean | Standard Deviation | milligram/liter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Duration of Intensive Care Unit (ICU) Stay | | | Posted | | Mean | Standard Deviation | days | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | C-reactive Protein (CRP) at Day 7 | | | Posted | | Mean | Standard Deviation | milligram/liter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | C-reactive Protein (CRP) at Day 14 | | | Posted | | Mean | Standard Deviation | milligram/liter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | C-reactive Protein (CRP) at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | milligram/liter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Sequential Organ Function Assessment (SOFA) Score on Day 7 | minimum 0 to maximum 24, higher scores mean worse outcomes | | Posted | | Count of Participants | | Participants | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Sequential Organ Function Assessment Score (SOFA) on Day 14 | minimum 0 to maximum 24, higher scores mean worse outcomes | | Posted | | Count of Participants | | Participants | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Sequential Organ Function Assessment Score (SOFA) on Day 28 | minimum 0 to maximum 24, higher scores mean worse outcomes | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Count of Participants | | Participants | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
|
| Secondary | COVID-19 World Health Organization (WHO) Disease Progression Scale at Day 7 | minimum 0 to maximum 10, higher scores mean worse outcomes | | Posted | | Count of Participants | | Participants | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | COVID-19 World Health Organization (WHO) Disease Progression Scale at Day 14 | minimum 0 to maximum 10, higher scores mean worse outcomes | | Posted | | Count of Participants | | Participants | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | COVID-19 World Health Organization (WHO) Disease Progression Scale at Day 28 | minimum 0 to maximum 10, higher scores mean worse outcomes | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Count of Participants | | Participants | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
|
| Secondary | Aspartate Aminotransferase (AST) at Day 7 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Aspartate Aminotransferase (AST) at Day 14 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Aspartate Aminotransferase (AST) at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | Units/liter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Alanine Aminotransferase (ALT) at Day 7 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Alanine Aminotransferase (ALT) at Day 14 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Alanine Aminotransferase (ALT) at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | Units/liter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Bilirubin at Day 7 | | | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Bilirubin at Day 14 | | | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Bilirubin at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Albumin at Day 7 | | | Posted | | Mean | Standard Deviation | gm/dl | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Albumin at Day 14 | | | Posted | | Mean | Standard Deviation | gm/dl | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Albumin at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | gm/dl | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Platelets at Day 3 | | | Posted | | Mean | Standard Deviation | 10^3 cells/uL | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Platelets at Day 7 | | | Posted | | Mean | Standard Deviation | 10^3 cells/uL | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Platelets at Day 14 | | | Posted | | Mean | Standard Deviation | 10^3 cells/uL | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Platelets at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | 10^3 cells/uL | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Serum Creatinine (S.Cr) at Day 3 | | | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Serum Creatinine (S.Cr) at Day 7 | | | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Serum Creatinine (S.Cr) at Day 14 | | | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Serum Creatinine (S.Cr) at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | milligram/deciliter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | D-dimer at Day 7 | | | Posted | | Mean | Standard Deviation | μg/mL | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | D-dimer at Day 14 | | | Posted | | Mean | Standard Deviation | μg/mL | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | D-dimer at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | μg/mL | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Creatine Kinase (Ck) at Day 3 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Creatine Kinase (Ck) at Day 7 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Creatine Kinase (Ck) at Day 14 | | | Posted | | Mean | Standard Deviation | Units/liter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Creatine Kinase (Ck) at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | Units/liter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Lactate Dehydrogenase (LDH) at Day 7 | | | Posted | | Mean | Standard Deviation | international units per liter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Lactate Dehydrogenase (LDH) at Day 14 | | | Posted | | Mean | Standard Deviation | international units per liter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Lactate Dehydrogenase (LDH) at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | international units per liter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Ferritin at Day 7 | | | Posted | | Mean | Standard Deviation | micrograms per liter | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Ferritin at Day 14 | | | Posted | | Mean | Standard Deviation | micrograms per liter | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Ferritin at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | micrograms per liter | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Incidence of Acute Kidney Injury (AKI) | Incidence of acute kidney injury (AKI) | | Posted | | Count of Participants | | Participants | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Incidence of Acute Liver Damage (ALD) | Incidence of acute liver damage (ALD) | | Posted | | Count of Participants | | Participants | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Day of Death | | | Posted | | Mean | Standard Deviation | day | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Secondary | Mortality at Discharge | | | Posted | | Count of Participants | | Participants | | up to 60 days | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Other Pre-specified | Glasgow Coma Score (GCS) at Day 3 | minimum 0 to maximum 15, higher scores mean better outcomes | | Posted | | Count of Participants | | Participants | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Other Pre-specified | Arterial Oxygen Pressure / Fraction Inspired of Oxygen (PaO2/FiO2) at Day 3 | | | Posted | | Mean | Standard Deviation | Ratio | | day 3 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Other Pre-specified | Arterial Oxygen Pressure / Fraction Inspired of Oxygen (PaO2/FiO2) at Day 7 | | | Posted | | Mean | Standard Deviation | Ratio | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Other Pre-specified | Arterial Oxygen Pressure / Fraction Inspired of Oxygen (PaO2/FiO2) at Day 14 | | | Posted | | Mean | Standard Deviation | Ratio | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Other Pre-specified | Arterial Oxygen Pressure / Fraction Inspired of Oxygen (PaO2/FiO2) at Day 28 | | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Mean | Standard Deviation | Ratio | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
|
| Other Pre-specified | Glasgow Coma Score (GCS) at Day 7 | minimum 0 to maximum 15, higher scores mean better outcomes | | Posted | | Count of Participants | | Participants | | day 7 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Other Pre-specified | Glasgow Coma Score (GCS) at Day 14 | minimum 0 to maximum 15, higher scores mean better outcomes | | Posted | | Count of Participants | | Participants | | day 14 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
| |
| Other Pre-specified | Glasgow Coma Score (GCS) at Day 28 | minimum 0 to maximum 15, higher scores mean better outcomes | patients who received casirivimab and imdevimab, not stayed at hospital until day of 28 | Posted | | Count of Participants | | Participants | | day 28 | | | | ID | Title | Description |
|---|
| OG000 | Casirivimab and Imdevimab | casirivimab and imdevimab, vials 1.2 gm (1200 mg of combined antibodies) diluted in 250 ml 0.9% sodium chloride solution as single I.V infusion over 30-60 minutes. Casirivimab and Imdevimab Drug Combination: antiviral Monoclonal Antibodies | | OG001 | Remdesivir | Remdesivir, vials Day1 (loading dose): 200 mg (two 100mg vials) diluted in 500ml 0.9% sodium chloride solution infused I.V over 60 minutes Day 2-5 or Day 2-10 (maintenance dose): 100 mg (one 100mg vial) in 250 ml 0.9% sodium chloride solution infused I.V over 30 minutes Remdesivir: antiviral drug | | OG002 | Favipravir | Favipravir, tablets Day 1 (loading dose): 1600 mg (8 tablets) or 1800 mg (9 tablets) orally or in Ryle tube / 12 hours Day 2-5 or day 2-10 (maintenance dose): 600 mg (3 tablets) or 800 mg (4 tablets) orally or in Ryle tube / 12 hours Favipiravir: antiviral drug |
|