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Through a comprehensive analysis of the pancreatic cystic fluid analysis, the role of the cystic fluid analysis is confirmed in terms of accurate diagnosis of pancreatic cysts, appropriate prediction of treatment response, and to select proper treatment indication through analytic results.
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| Measure | Description | Time Frame |
|---|---|---|
| diagnostic accuracy by cystic fluid analysis | diagnostic accuracy by cystic fluid analysis in comparison with pathologic diagnosis | up to 5 years after cystic fluid analysis |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | overall survival until death | up to 5 years after cystic fluid analysis or surgical resection |
| Disease free survival | Period till tumor recurrence after surgical resection or intervention |
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Inclusion Criteria:
Exclusion Criteria:
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patients who were diagnosed with pancreatic cystic lesions and managed in Seoul National University Hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | 101 | South Korea |
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| ID | Term |
|---|---|
| D010181 | Pancreatic Cyst |
| ID | Term |
|---|---|
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
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cystic fluid DNA from cellular component in cystic fluid
| up to 5 years after cystic fluid analysis or surgical resection |
| Malignant transformation rate | the prevalence of malignant transformation during follow-up period (percent) | up to 5 years after cystic fluid analysis |
| Prediction for treatment response in case of surgical resected or EUS-guided ethanol ablated pancreatic cysts | evaluation of treatment response for surgery of EUS guided therapy according to RECIST criteria v1.1 | up to 5 years after cystic fluid analysis or EUS guided ablative therapy |
| Cytology of cystic fluid | result of cytology of cystic fluid | within 2 months after study enrollment |
| Chemical profile of CEA in cystic fluid | level of CEA in cystic fluid | within 2 months after study enrollment |
| Chemical profile of Amylase in cystic fluid | level of amylase in cystic fluid | within 2 months after study enrollment |
| Chemical profile of glucose in cystic fluid | level of glucose in cystic fluid | within 2 months after study enrollment |
| DNA mutation profile of cystic fluid | targeted NGS for KRAS, NRAS, CDKN2A, TP53, SMAD4, RNF43, PTEN, PIK3CA, VHL, Aneuploid | within 2 months after study enrollment |