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Historically, CKRT and hemodialysis were performed in small infants and newborns with devices developed for adults with high rates of complications and mortality.
We aim to retrospectively report the first multicenter French experience of CARPEDIEM® use and evaluate the efficacy, feasibility, outcomes, and technical considerations of this new device in a population of neonates and small infant. Compared to adult's device continuous renal replacement therapy with an adapted machine allowed successful blood purification without severe complications even in low birth weight neonates.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | We have included 25 neonates and small infants having received CARPEDIEM® machine in France in a multicentric experience |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CARPEDIEN | Device | Continuous renal replacement therapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Survival | 3 years | |
| Serum creatinine | 3 years | |
| Serum potassium | 3 years | |
| Blood urea nitrogen | 3 years | |
| Ammonia levels | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Ultrafiltration flow | the substitution range with the effluent volume in ml/kg/h ( compared to the KDIGO recommend of 25-35 ml/kg/h) | 3 years |
| Blood flow | The range of blood flow in ml/kg/min ( compared to the recommend blood flow of 3-10 ml/kg/min). |
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Inclusion criteria:
Exclusion Criteria:
-Renal replacement therapy with another device than Carpediem machine
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The population will be selected in a department of pediatric and neonatal unit intensive care and whom need a renal replacement therapy
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nice | Nice | France |
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| 3 years |
| Anticoagulation | The dose of continuous heparin anticoagulation in UI/Kg/h to prevent circuit clotting. | 3 years |
| Number of sessions | 3 years |
| Time of treatments | 3 years |
| CKRT modality | 3 years |
| Vascular access | The localization of a vascular access ( intern jugular, subclavian, umbilical or femoral). | 3 years |
| Priming circuit | The priming circuit ( normal salin, albumin, Isofundin or packed red blood cells). | 3 years |
| Size of the circuit | 3 years |
| Death | 3 years |
| Clotting circuit and other dysfunction circuit |
| 3 years |
| ID | Term |
|---|---|
| D020925 | Hypoxia-Ischemia, Brain |
| D018805 | Sepsis |
| D007674 | Kidney Diseases |
| D008659 | Metabolic Diseases |
| D005330 | Fetofetal Transfusion |
| D006331 | Heart Diseases |
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D002545 | Brain Ischemia |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D002534 | Hypoxia, Brain |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000860 | Hypoxia |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D000751 | Anemia, Neonatal |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D012140 | Respiratory Tract Diseases |
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