Open-label study of an investigational product (IP), QLS-101, with 28-day every morning (QAM) dosing to both eyes (OU) in adolescents with SWS who have clinical evidence of glaucoma and/or ocular hypertension (OHT) related to SWS elevated EVP in at least one eye.

Inclusion Criteria:

• Between 12 and 19 years of age at Screening.
• Diagnosed with SWS
• Elevated IOP
• Willing to continue current dosing regimen of IOP-lowering medications
• Able to provide informed consent and follow study instructions

Exclusion Criteria:

• Expected to undergo IOP-lowering surgery
• Incisional or laser surgery of any type 4 months prior to study
• Ocular infection, inflammation, clinically significant blepharitis or conjunctivitis, history of herpes simplex keratitis in either eye
• History of or active clinically significant ocular disease
• Use of topical ocular corticosteroids in the 6 weeks prior to study
• Patient cannot be applanated or tolerate IOP measurements
• Patient is pregnant or lactating
• Uncontrolled systemic disease that can interfere with study participation
• Inability to self-dose or identify a caregiver for all study eye drop administration