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The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
Helicobacter pylori (HP) infection is a common global infectious disease, which is an important cause of chronic gastritis, peptic ulcer and gastric cancer. At present, due to the non-standard Helicobacter pylori eradication program in clinical work, poor patient compliance and other reasons, the phenomenon of HP eradication treatment failure is more and more common. However, there is still no conclusion on the most appropriate time for remedial treatment inpatients with Hp eradication failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group A | Within 3 months of treatment failure in the course of Helicobacter pylori infection,Patients will receive esomeprazole (Nexium) 40mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, amoxicillin1000mg po bid and tetracycline 500 mg po qid (or tetracycline 500 mg po tid) for 14d. |
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| group B | Within 3 to 6 months of treatment failure in the course of Helicobacter pylori infection,Patients will receive esomeprazole (Nexium) 40mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, amoxicillin1000mg po bid and tetracycline 500 mg po qid (or tetracycline 500 mg po tid) for 14d. |
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| group C | Within 6 to 12 months of treatment failure in the course of Helicobacter pylori infection,Patients will receive esomeprazole (Nexium) 40mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, amoxicillin1000mg po bid and tetracycline 500 mg po qid (or tetracycline 500 mg po tid) for 14d. |
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| group D | After 12 months of treatment failure in the course of Helicobacter pylori infection,Patients will receive esomeprazole (Nexium) 40mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, amoxicillin1000mg po bid and tetracycline 500 mg po qid (or tetracycline 500 mg po tid) for 14d. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remedial treatment within 3 months | Other | Remedial therapy was performed within 3 months |
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| Measure | Description | Time Frame |
|---|---|---|
| The most suitable re-eradication time | The most suitable re-eradication time#The unit is month# will be assessed by paired comparison method . | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Eradication rates in three groups | Both intention to treat(ITT) and per-protocol(PP) analyses will be used for the assessment of the eradication rates of Helicobacter pylori infections in three groups | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged 18-70 with previous Helicobacter pylori eradication failure.
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| Remedial treatment within 3 to 6 months |
| Other |
Remedial therapy was performed within 3 to 6 months |
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| Remedial treatment within 6 to 12 months | Other | Remedial therapy was performed within 6 to 12 months |
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| Remedial treatment after 12 months | Other | Remedial therapy was performed after 12 months |
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