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| ID | Type | Description | Link |
|---|---|---|---|
| J3X-MC-LYGA | Other Identifier | Eli Lilly and Company | |
| 2022-000500-36 | EudraCT Number |
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The main purpose of this study is to evaluate the safety and tolerability of LY3873862 when administered either in single or multiple doses in healthy participants. The study will also assess how fast LY3873862 gets into the blood stream and how long it takes the body to remove it. The study is open to healthy participants. The study will last up to approximately 58, 72, and 72 days for Part A, B, and C, respectively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LY3873862 (Part A) | Experimental | LY3873862 administered orally as single dose. |
|
| Placebo (Part A) | Placebo Comparator | Placebo administered orally. |
|
| LY3873862 (Part B) | Experimental | LY3873862 administered orally as multiple doses. |
|
| Placebo (Part B) | Placebo Comparator | Placebo administered orally. |
|
| LY3873862 (Part C) | Experimental | LY3873862 administered orally as multiple doses. |
|
| Placebo (Part C) | Placebo Comparator | Placebo administered orally. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LY3873862 | Drug | Administered orally. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration | A summary of TEAEs, SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module | Baseline through 72 days |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Zero to Infinity (AUC[0-â]) of LY3873862 | PK: AUC[0-â] of LY3873862 | Predose up to 96 hours postdose |
| PK: Area Under the Concentration versus Time Curve at Steady State (AUCĪ) of LY3873862 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) | Eli Lilly and Company | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hammersmith Medicines Research | London | NW10 7EW | United Kingdom |
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| Placebo | Drug | Administered orally. |
|
PK: (AUCĪ) of LY3873862 |
| Predose up to 96 hours postdose |
| PK: Maximum Observed Concentration (Cmax) of LY3873862 | PK: Cmax of LY3873862 | Predose up to 96 hours postdose |
| PK: Time of Maximum observed Concentration (Tmax) of LY3873862 | PK: Tmax of LY3873862 | Predose up to 96 hours postdose |