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| ID | Type | Description | Link |
|---|---|---|---|
| 00116801 | Other Identifier | Medical University of South Carolina | |
| HM20022956 | Other Identifier | Virginia Commonwealth University |
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| Name | Class |
|---|---|
| City of Hope Medical Center | OTHER |
| Medical University of South Carolina | OTHER |
| National Cancer Institute (NCI) | NIH |
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The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
Cigarette smoking is a leading cause of morbidity and mortality from lung cancer among adults in the US. Stress relief and smoking cessation is the best preventive strategy for reducing lung cancer risk and addressing racial disparities in outcomes. Despite this, racial differences are found among those that make quit attempts. Stress has been found to be related to smoking initiation, maintenance, and relapse. Yet, differences in stress responses have not been examined between African American and white smokers. Therefore, this study will examine racial differences in stress responses and smoking behaviors between African American and white male smokers
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| Measure | Description | Time Frame |
|---|---|---|
| Examining racial differences in acute stress responses | Examine racial differences in acute stress responses using a validated psychological stress challenge called the Trier Social Stress Test (TSST) | Within 1 month following baseline |
| Examining changes in daily cortisol patterns according to race | Examine racial differences in daily diurnal cortisol slopes to evaluate hypothalamic-pituitary-adrenal-axis dysregulation and acute stress | Baseline, 4- and 8 weeks post Trier Social Stress Test laboratory visit |
| Examine changes in stress responses and smoking behaviors as it relates to social determinant factors | Patients will be administered a survey using validated measures to examine socioeconomic, structural, and psychosocial stressors that impact daily stress and smoking behaviors | Baseline, 4- and 8-weeks post Trier Social Stress Test laboratory visit |
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Inclusion Criteria:
Exclusion Criteria:
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African American and white male daily smokers who are between the ages of 18-75 and who smoke at least 5 to 10 cigarettes per day.
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| Name | Affiliation | Role |
|---|---|---|
| Vanessa Sheppard, PhD | Virginia Commonwealth University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Southern California | Los Angeles | California | 90089 | United States | ||
| Medical University of South Carolina |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Nov 9, 2021 | Jun 29, 2022 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Nov 29, 2021 | Jun 29, 2022 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D012907 | Smoking |
| D016540 | Smoking Cessation |
| D015775 | Fractures, Stress |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D015438 | Health Behavior |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
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Saliva will be conducted for analyzing biomarkers of stress (i.e. cortisol, alpha-amylase), and biomarkers related to smoking (i.e. cotinine)
Urine will be collected to determine the presence of illicit substances as an indicator of exclusion/inclusion into the study.
Patients that provide consent will have additional saliva and urine collected and stored in a centralized biorepository for future research
| Charleston |
| South Carolina |
| 29425 |
| United States |