Effects of Contrast Media Temperature on Image Quality and Clinical Adverse Events in Coronary CTA

Department of Radiology

Extrinsic prewarming of iodinated CT contrast media (CM) to body temperature reduces viscosity and injection pressures. However, guideline recommendations on the necessity to prewarm iodinated CM are conflicting. And studies examining the effect of extrinsic warming CM for coronary CTA(CCTA) on clinical adverse events and image quality are lack.

Enrolled patients of chest pain or coronary artery disease screening were eligible for this a double-blinded, randomized noninferiority trial, and equally allocated into two group randomly: BBT-CM (basic body temperature) group received 37°C CM; RT-CM (room temperature) group received ~23°C CM. A state-of-the-art individualized CM (iopamidol at 370 mg I/mL) injection protocol was used, based on body weight.

Inclusion Criteria:

• Coronary symptomatic patients (i.e., chest pain).
• Patients for Coronary artery disease screening

Exclusion Criteria:

• Hemodynamic instability
• Renal insufficiency (estimated glomerular filtration rate <30 mL/min per 1.73 m2)
• Prior adverse reactions to iodinated CM
• Age younger than 18 years
• Inability to place an 18-gauge needle.