Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).

Mean scores will be compared between the groups using the Mann Whitney U test

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).

Comparing the distribution of the number of days participants were affected by each side effect

mann-whitney U

Comparing the distribution of the number of days participants were affected by each side effect

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, all participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month.

Preoperatively, participants were treated with oral analgesics (400 mg celecoxib, 75 mg pregabalin, and 9 mg oxycodone extended-release). Intraoperatively, participants were administered 10 mg of dexamethasone and 1000 mg of acetaminophen intravenously in addition to a local periarticular injection (a solution containing 60 mg of 0.5% ropivacaine, 1 mg of epinephrine [1 mg/mL], and 30 mg of ketorolac). Postoperatively, participants were discharged with oral medications that consisted of 4 mg dexamethasone twice daily for 4 days (participants that had an overnight hospital stay instead received a one-time 10 mg intravenously dexamethasone dose on postoperative day 1), 75 mg pregabalin twice daily for 14 days, 2 mg tizanidine every 6 hours for 14 days, 200 mg magnesium twice daily for 14 days, 600 mg ibuprofen every 6 hours (not to exceed 3200 mg per day) for 1 month, and 975 mg acetaminophen every 8 hours (not to exceed 3000 mg per day) for 1 month. Participants were given an additional prescription for 28 pills of 5 mg oxycodone to be taken for severe pain (≥ 6 on visual analog scale [VAS]). Participants in this treatment group could opt for receiving a rescue opioid prescription of 28 pills of 5 mg oxycodone if they felt that their pain was not sufficiently managed (severe pain, ≥ 6 on VAS).