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White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). WMH tend to show a peri-basal ganglia pattern in HA, whereas a multiple subcortical spots pattern can be observed in CAA. Periventricular WMH (PVWMH) have been reported to be posterior predominant using a semiautomated segmentation method and logarithmic transformation, not used in daily clinical practice. In these studies including CAA patients, patients initially presented with haemorrhage-related symptoms. In another study analysing PVWMH and cerebral amyloid evidence in patients with mild cognitive impairment, frontal PVWMH burden was associated with high uptake on florbetapir-PET whereas parietal and occipital PVWMH burden was associated with low CSF-amyloid-beta.
The aim of this study is the descriptive comparative analysis of the distribution of PVWMH between CAA and HA patients with radiological tools available in daily practice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cerebral amyloid angiopathy | Patient with cerebral amyloid angiopathy |
| |
| Hypertensive arteriopathy | Patients with hypertensive arteriopathy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| None, pure observational study | Other | None, pure observational study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Distribution of PVWMH | Maximal distance between the outer PVWMH border and the border of the lateral ventricle (on the axis oriented at 90° to the border of the ventricle) | Base line, Day 0 |
| Distribution of PVWMH - total PVWMH extent. | The sum of the PVWMH measurements around the four ventricles horns (i.e. bilateral anterior and posteriors horns) resulted in total PVWMH extent. | Base line, Day 0 |
| Corpus callosum (CC) WMH | Distance between the border of the third ventricle and the outer border of the WMH on the rostro-caudal axis, resulting in anterior and posterior CC-PVWMH extent measurements. | Base line, Day 0 |
| Corpus callosum (CC) WMH - total CC-PVWMH extent. | The sum of the anterior and posterior CC-PVWMH measurements resulted in the total CC-PVWMH extent. | Base line, Day 0 |
| Ratios | Calcul of posterior/anterior ratios for both the PVWMH and CC-PVWMH | base line, day 0 |
| Anterior PVWMH | Comparison of anterior PVWMH between CAA group and HA group. | Base line, Day 0 |
| Posterior PVWMH | Comparison of posterior PVWMH between CAA group and HA group. | Base line, Day 0 |
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Inclusion Criteria:
CAA and HA patients, managed at Nîmes University Hospital between January 2015 and March 2022.
Exclusion Criteria:
CAA and HA patients, treated at the CHU of Nîmes between January 2015 and March 2022, not objecting to the use of their health data
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CAA and HA patients, managed at Nîmes University Hospital between January 2015 and March 2022
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| Name | Affiliation | Role |
|---|---|---|
| Anissa MEGZARI | Centre Hospitalier Universitaire de Nīmes | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nîmes | Nîmes | 30029 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38920025 | Result | Deasy L, Laurent-Chabalier S, Wacongne A, Parvu T, Mura T, Thouvenot E, Renard D. Diagnostic Accuracy of Posterior/Anterior Periventricular WMH Ratio to Differentiate CAA From Hypertensive Arteriopathy. Stroke. 2024 Aug;55(8):2086-2093. doi: 10.1161/STROKEAHA.123.046379. Epub 2024 Jun 26. |
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| ID | Term |
|---|---|
| D016657 | Cerebral Amyloid Angiopathy |
| ID | Term |
|---|---|
| D002539 | Cerebral Arterial Diseases |
| D020765 | Intracranial Arterial Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
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| Total PVWMH |
Comparison of total PVWMH between CAA group and HA group. |
| Base line, Day 0 |
| Posterior/anterior PVWMH ratio | Comparison of the posterior/anterior PVWMH ratio between CAA and HA groups. | Base line, Day 0 |
| anterior CC-PVWMH | Comparison of anterior CC-PVWMH between CAA group and HA group. | Base line, Day 0 |
| Posterior CC-PVWMH | Comparison of posterior CC-PVWMH between CAA group and HA group. | Base line, Day 0 |
| Total PVWMH and posterior/anterior CC-PVWMH ratio | Comparison of total PVWMH and posterior/anterior CC-PVWMH ratio between CAA group and HA group. | Base line, Day 0 |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000686 | Amyloidosis |
| D057165 | Proteostasis Deficiencies |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |