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The recent four RCTs evaluating effects of RBC storage age on morbidity and mortality found no statistically significant adverse effects of longer stored RBC compared to shorter storage ages. Unfortunately, none of these RCTs had sufficient numbers of subjects receiving RBC at either storage age extreme to identify consequences of RBC transfusion at these limits. To better investigate effects of RBC storage age on clinical outcomes, this study will perform secondary meta-analyses of merged common patient data elements -individual patient data (IPD) meta-analysis (IPDMA) - from the nearly 33,000 subjects enrolled in the four RCTs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Reference group | Transfused RBC stored 8-35 days |
| |
| less than or equal 7 days | Transfused RBC stored =<7 days |
| |
| more than 7 days | Transfused RBC stored <7 days |
| |
| less that or equal 10 days | Transfused RBC stored =<10 days |
| |
| more that 10 days | Transfused RBC stored >10 days |
| |
| more than 35 days | Transfused RBC stored >35 days |
| |
| less than or equal 35 days |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention | Other | This is an observational retrospective study (meta-analysis) |
|
| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | Estimate the effect of transfused RBC storage-age on time to all-cause mortality | 28 days after transfusion |
| Hospital length of stay | Estimate the effect of transfused RBC storage-age on hospital stay | after transfusion through 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality at 28 days for long-storage | all-cause mortality at 28 days comparing subjects who received (one or more) RBC unit ≥ 35 days vs. no unit > 35 days | 28 days after transfusion |
| 28 day mortality for short-storage |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects in the recent four RCTs who are 18 years or older and have received at least one RBC transfusion.
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| Name | Affiliation | Role |
|---|---|---|
| Marie Steiner, MD | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
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Transfused RBC stored =<35 days
|
| less than 18 days | Transfused RBC stored <18 days |
|
| more than or equal 18 days | Transfused RBC stored =>18 days |
|
28 day mortality for subjects who received (one or more) RBC unit ≤ 7 days vs. no unit ≤ 7 days
| 28 days after transfusion |