A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

The Role of Detergents in the Pathogenesis of Eosinophilic Esophagitis

The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.

Inclusion Criteria:

• Normal, healthy volunteers.
• Able to swallow pills.

Exclusion Criteria:

• Personal history of esophageal disease including but not limited to eosinophilic esophagitis, esophageal dysmotility, or GERD/reflux.
• History of dysphagia (i.e., difficulty swallowing), chronic vomiting, chronic abdominal pain, unintentional weight loss.
• Celiac disease, inflammatory bowel disease, irritable bowel syndrome, esophageal varices, chronic aspiration, connective tissue disorder, or known parasitic infection.
• Gelatin allergy.
• Use of a toothpaste containing SLS within 2 weeks of the study.
• Pregnancy.