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The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Toothpaste detergents with Eosinophilic Esophagitis Testing | Experimental | Subjects will complete an esophageal string test prior to and after completing a high resolution esophageal manometry then brushing their teeth using Colgate toothpaste. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Esophageal String Test (EST) | Diagnostic Test | Non-invasive, FDA-registered sampling method to evaluate eosinophilic inflammation in the esophagus. The EST is performed by having an individual swallow a capsule attached to a string which captures secretions from the esophagus. The end of the string is taped to the cheek and the capsule is swallowed with water. After 1 hour, the EST will be removed, and the string will be processed for laboratory analysis. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Mucosal impedance 15 minutes after exposure | Recorded from the High Resolution Esophageal Manometry testing that measures eosinophils on histology | Baseline, 15 minutes after teeth brushing |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Mucosal impedance 30 minutes after exposure | Recorded from the High Resolution Esophageal Manometry testing that measures eosinophils on histology | Baseline, 30 minutes after teeth brushing |
| Change in Mucosal impedance 45 minutes after exposure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Benjamin Wright, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic - Clinical Trials | View source |
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| ID | Term |
|---|---|
| D057765 | Eosinophilic Esophagitis |
| ID | Term |
|---|---|
| D004941 | Esophagitis |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D012969 | Sodium Fluoride |
| ID | Term |
|---|---|
| D005459 | Fluorides |
| D006858 | Hydrofluoric Acid |
| D017611 | Fluorine Compounds |
| D007287 | Inorganic Chemicals |
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|
|
| Colgate | Other | 2 grams of toothpaste (pea sized amount) for 2 minutes |
|
| High Resolution Esophageal Manometry (HREM) | Diagnostic Test | Thin flexible tube with sensors placed in the nose and swallowed for esophagus placement to conduct reading regarding the lining of the esophagus taken for approximately 10 minutes |
|
Recorded from the High Resolution Esophageal Manometry testing that measures eosinophils on histology |
| Baseline, 45 minutes after teeth brushing |
| Change in Mucosal impedance 60 minutes after exposure | Recorded from the High Resolution Esophageal Manometry testing that measures eosinophils on histology | Baseline, 60 minutes after teeth brushing |
| Change in IL-33 levels | Measured from esophageal string test eluates | Baseline, approximately 60 minutes after teeth brushing |
| D005759 |
| Gastroenteritis |
| D004802 | Eosinophilia |
| D007960 | Leukocyte Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D017670 |
| Sodium Compounds |
| D002327 | Cariostatic Agents |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |