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| Name | Class |
|---|---|
| Peking University | OTHER |
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Childhood obesity is a significant public health concern worldwide. In China, childhood obesity has dramatically increased as the economy has grown quickly over the past decades. Nonalcoholic fatty liver disease (NAFLD) is tightly associated with obesity, in China, the prevalence of NAFLD in obesity children is 40.0%，the main interventions for NAFLD are lifestyle interventions. Effective strategies to helping students lose weight and alleviate NAFLD through lifestyle interventions may help promote the physical and mental health of obese students.
This study aimed (1)to assess the effectiveness of the intervention compared with the usual practice in treating childhood overweight and obesity; (2) to determine the sustainability of the treatment in preventing overweight and obesity; (3) to help alleviate or reverse NAFLD in obesity children.
Children with overweight and obesity in six primary schools in Ningbo City, Zhejiang Province will be seleted and randomly divided into two groups: the treatment group and the usual practice group. The participants of the study were students in the third grade of primary school, and the treatment will last for one academic year. This treatment activity on lifestyle interventions will target the dietary and exercise factors of childhood obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment group | Experimental | Treatment activity on lifestyle interventions will target the dietary and exercise factors of childhood obesity. |
|
| Usual practice group | No Intervention | No intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lifestyle intervention | Behavioral | This intervention programme will target the influencing factors of childhood obesity to influence the knowledge, attitude and behaviours of school children. Students in the treatment group will receive the following interventions:
|
| Measure | Description | Time Frame |
|---|---|---|
| change in body mass index (BMI) |
| 3 months，9 months , 24 months and 36 months |
| change in controlled attenuation parameters (CAP) |
| 3 months，9 months , 24 months and 36 months |
| Change in liver stiffness measurement (LSM) |
| 3 months，9 months , 24 months and 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in BMI z- score |
| 3 months，9 months , 24 months and 36 months |
| change in blood glucose |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ningbo First Hospital | Ningbo | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42077646 | Derived | Zhang PP, Li L, Fu H, Nur E, Xu D, Wang Y, Gu J, Xu M, Zhou Y, Shen F, Li X, Xing Y, Jin S, Li J, Song Q, Li H, Wen LM, Wang H, Wang HJ. Effect of an mHealth-assisted multifaceted lifestyle intervention on body-mass index, hepatic fat content and stiffness in children with overweight or obesity: a cluster randomised controlled trial. EClinicalMedicine. 2026 Mar 21;94:103840. doi: 10.1016/j.eclinm.2026.103840. eCollection 2026 Apr. | |
| 38504343 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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|
caculated by terminal value minus baseline value
| 9 months |
| change in blood lipids |
| 9 months |
| change in fasting insulin | caculated by terminal value minus baseline value | 9 months |
| change in body fat percentage | caculated by terminal value minus baseline value | 3 months and 9 months |
| change in waist circumference | caculated by terminal value minus baseline value | 3 months，9 months , 24 months and 36 months |
| change in weight | caculated by terminal value minus baseline value | 3 months，9 months , 24 months and 36 months |
| change in cardiorespiratory endurance test | caculated by terminal value minus baseline value | 3 months，9 months , 24 months and 36 months |
| change in ALT(alanine transaminase) | caculated by terminal value minus baseline value | 9 months |
| Derived |
| Zhang PP, Wang YX, Shen FJ, Xing YF, Gu JY, Li XY, Jin H, Jin SF, Xu M, Wang HJ, Wang H, Li L. Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study). Trials. 2024 Mar 20;25(1):196. doi: 10.1186/s13063-024-08046-4. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |