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| Name | Class |
|---|---|
| University of Debrecen | OTHER |
| Damascus University | OTHER |
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Although ectopic pregnancy was considered a leading cause of first-trimester maternal mortalities, current technological improvements allowed early diagnosis and opened a door for applying less invasive approaches. A tubal pregnancy could be managed either expectantly, medically, or surgically. The expectant management of ectopic pregnancy relies on the fact that a considerable proportion of ectopic gestations terminate by spontaneous tubal abortion. This approach is usually kept for stable cases with a small gestational sac and low beta-human chorionic gonadotropin (beta-HCG) serum levels. For hemodynamically unstable patients, higher levels of beta-HCG, and larger gestational sacs, surgery is often considered as the treatment of choice (16).
Considering this background, the study aims to analyze the subsequent natural reproductive outcomes of patients that had a previous tubal ectopic pregnancy and were managed either expectantly or surgically. Moreover, it amis to determine the factors that could influence the fertility potential of these patients in each treatment group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ectopic pregnancy | Women with diagnosed tubal ectopic pregnancy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Expectant management | Other | Follow-up with beta-HCG dosages and transvaginal ultrasound scans |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Presence of a gestational sac under ultrasonography | Within one year after the previous episode of tubal ectopic pregnancy |
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Inclusion Criteria:
Exclusion Criteria:
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Women with either surgically-confirmed tubal ectopic pregnancy or a diagnosis of tubal ectopic pregnancy based on a positive beta-HCG serum measurement with the visualization of an adnexal mass resembling a tubal gestational sac and an empty uterine cavity upon transvaginal ultrasonographic scan.
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| Name | Affiliation | Role |
|---|---|---|
| Antonio Simone Laganà , M.D., Ph.D. | University of Palermo | Principal Investigator |
| Antoine Naem, M.D. | Damascus University | Study Chair |
| Péter Török, M.D. | University of Debrecen | Study Director |
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| ID | Term |
|---|---|
| D011271 | Pregnancy, Ectopic |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D057832 | Watchful Waiting |
| D058994 | Salpingectomy |
| D012489 | Salpingostomy |
| ID | Term |
|---|---|
| D017063 | Outcome Assessment, Health Care |
| D010043 | Outcome and Process Assessment, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
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| Salpingectomy | Procedure | Removal of the affected Fallopian tube by laparoscopy |
|
| Salpingostomy | Procedure | Removal of the ectopic pregnancy from the Fallopian tube, without removing the whole Fallopian tube, by laparoscopy |
|
| D013509 | Gynecologic Surgical Procedures |
| D013519 | Urogenital Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D000714 | Anastomosis, Surgical |