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The investigators will conduct a pilot experiment for a novel and personalized method for voice restoration using machine learning applied to surface EMG (sEMG) signal from articulatory muscles of the face and the neck allowing recognition of silent speech. The investigators predict that the use novel personalized method for voice restoration will be feasible and successful for patients.
This is a prospective pilot study evaluating the feasibility of a personalized voice restoration device and patients' experience with it. Study participation will include a one-time visit where subjects will read passages and phrases. Acoustic and signal data will be captured. Machine learning will be applied to the data to classify words. Subjects will also participate in a qualitative interview about their experience with voice restoration devices.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Aphonia or Dysphonia | Experimental | Participants with Aphonia or Dysphonia will be asked to recite phrases with sEMG attached to articulatory muscles. |
|
| Healthy Volunteers | Placebo Comparator | Healthy Volunteer will be asked to recite phrases with sEMG attached to articulatory muscles. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surface Electromyography | Device | Surface ElectroMyoGraphy (SEMG) is a non-invasive technique for measuring muscle electrical activity that occurs during muscle contraction and relaxation cycles. Electrodes will be attached with a AgCl gel to muscles used for articulation. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Words and Numbers Correctly Identified | Accuracy of sEMG signal will be determined by subjects reciting common phrases. Subjects will recite the "Rainbow Passage" 10 times. Subjects will be asked to count from 1-10 once. Subjects will recite the alphabet once. | "During Procedure/use of Surface ElectroMyoGraphy" |
| Subject experience with voice restoration devices: Qualitative | Subject will be asked to complete a semi-structured interview about their experience with voice restoration devices. Categories of response include voice/communication history, experience with previous voice restoration devices, experience with our device, and suggestions for improvement. | 10 minutes after the time of intervention |
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Inclusion Criteria:
Group A: Healthy Volunteers
Group B: Subjects with Aphonia or Dysphonia
Exclusion Criteria:
- Group A: Healthy Volunteers
1. Voice impairment
Group B: Subjects with Aphonia or Dysphonia
1. Subjects whose face muscles are entirely paralyzed
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anaïs Rameau, MD | Contact | 646-962-7464 | anr2783@med.cornell.edu |
| Name | Affiliation | Role |
|---|---|---|
| Anaïs Rameau, MD | Weill Medical College of Cornell University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Weill Cornell Medicine | New York | New York | 10022 | United States |
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| ID | Term |
|---|---|
| D055154 | Dysphonia |
| D001044 | Aphonia |
| ID | Term |
|---|---|
| D014832 | Voice Disorders |
| D007818 | Laryngeal Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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| ID | Term |
|---|---|
| D004576 | Electromyography |
| ID | Term |
|---|---|
| D004568 | Electrodiagnosis |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D009213 | Myography |
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| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |