Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects

Efficacy and Side Effect Profile of Varying Dose of Pregabalin for the Treatment of Acute Postoperative Pain Following Spinal Surgery

The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.

Patients experience considerable postoperative pain after spine surgery. Because the spine is located at the center of the body and supports body weight, severe postoperative pain hinders upper body elevation and gait which can lead to various complications such as pulmonary deterioration or pressure sores. It is important to effectively control postoperative pain to prevent such complications. Gabanoids are widely used as preemptive multimodal analgesia while their effects and side effects are known to be dose dependent. The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.

Inclusion Criteria:

• Adult patient undergoing spine surgery at out institution for degenerative lumbar disorder.

Exclusion Criteria:

• ASA classification over 2
• Patients with dizziness or frequent headache
• Active alcohol or drug usage
• Intake of any analgesics daily or 48 hours before surgery
• Impaired renal and/or hepatic function
• Diagnosed and being treated for anxiety or depression disorders
• Coverage from worker's compensation insurance or car insurance.