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Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients. As a direct sound-based approach, CDIM does not rely on autobiographical memory and may have wider applicability and generalizability. We wish to examine if CDIM decreases anxiety in 15 cognitively healthy individuals and 15 Alzheimer Disease patients with anxiety (AD-A).
The goal of this study is to identify the neural mechanisms of induced calmness through live clinically designed improvisatory music (CDIM) in cognitively healthy individuals and persons with Alzheimer's dementia suffering from agitation. This study is novel as most music interventions for dementia use familiar music and the underlying neural mechanism of calmness induced by music is not well known. We plan to investigate changes in 3 major large-scale brain networks using functional magnetic resonance imaging (fMRI). The major questions we plan to answer are as follows: 1. How does improvisatory music change the connectivity within brain emotion related networks in neurotypical individuals? 2. Does improvisatory music induce a state of calmness in individuals with Alzheimer's dementia and how? Based on objective evidence provided by this study we can justify further usage of music for patients with Alzheimer's, in particular, in the form of improvisation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alzheimer Disease (AD) | Experimental |
| |
| Cognitively Healthy (CH) | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinically Designed Improvisatory Music | Behavioral | Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Neuropsychiatric Inventory (NPI) [NPI-1: pre-intervention; NPI-2: post-intervention] | Change in NPI (NPI-2 minus NPI-1) | Through study completion (3 years) |
| Change in Beck Anxiety Inventory [BAI-1: pre-intervention; BAI-2: post-intervention] | Change in BAI (BAI-2 minus BAI-1) | Through study completion (3 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Systolic Blood Pressure [SBP-1: pre-intervention; SBP-2: post-intervention] | Change in SBP (SBP-2 minus SBP-1) | Through study completion (3 years) |
| Change in Heart rate [HR-1: pre-intervention; HR-2: post-intervention] |
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Inclusion Criteria:
Cognitively healthy individuals
Cognitively healthy control participants evaluated through the Northwestern Mesulam Center. BAI > 8.
Exclusion Criteria: hearing loss
Individuals with mild to moderate Alzheimer's disease
This group will similarly be recruited through the Mesulam Center. All individuals recruited by the research Core at the center are well characterized tests standardized across all NIH funded Alzheimer Centers across the nation. Individuals with mild to moderate neurocognitive disorder due to AD will have an MMSE greater than >15 and Clinical Dementia Rating (CDR) between 0.5 and 2.. They will also have a history of neurocognitive-related agitation/anxiety, and a Beck Anxiety Index (BAI) greater than 8, suggestive of at least a mild level of anxiety.
Exclusion criteria: MMSE<15, CDR>2, hearing loss
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| Name | Affiliation | Role |
|---|---|---|
| Borna Bonakdarpour, MD, FAAN | Northwestern Mesulam Center for Cognitive Neurology and Alzheimer Disease | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mesulam Center for Cognitive Neurology and Alzheimer's Disease | Chicago | Illinois | 60611 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34966344 | Background | Bonakdarpour B, McFadden A, Zlotkowski S, Huang D, Shaker M, Shibata B, Haben W, Brashear C, Sandoval A, Breitenbach C, Rodriguez C, Viamille J, Porter M, Galic K, Schaeve M, Thatcher D, Takarabe C. Neurology Telemusic Program at the Time of the COVID-19 Pandemic: Turning Hospital Time Into Aesthetic Time During Crisis. Front Neurol. 2021 Dec 13;12:749782. doi: 10.3389/fneur.2021.749782. eCollection 2021. | |
| 21889116 |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D001008 | Anxiety Disorders |
| D003704 | Dementia |
| D011595 | Psychomotor Agitation |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
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15 individuals with Alzheimer Disease (AD) and 15 cognitively healthy individuals.
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Change in HR (HR-2 minus HR-1)
| Through study completion (3 years) |
| Change Respiratory Rate [RR-1: pre-intervention; RR-2: post-intervention] | Change in RR (RR-2 minus RR-1) | Through study completion (3 years) |
| Change in Skin conductance [SC-1: pre-intervention; SC-2: post-intervention] | Change in SC (SC-2 minus SC-1) | Through study completion (3 years) |
| Change in Resting state functional connectivity MRI | Functional Connectivity within three resting state networks: Change in Default Network (DN), Change in Salience Network (SN), and Change in Reward Network (RN). | Through study completion (3 years) |
| Background |
| Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, Miller DS. Neuropsychiatric symptoms in Alzheimer's disease. Alzheimers Dement. 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410. |
| 25725917 | Background | Baird A, Samson S. Music and dementia. Prog Brain Res. 2015;217:207-35. doi: 10.1016/bs.pbr.2014.11.028. Epub 2015 Jan 31. |
| 12151841 | Background | Assal F, Cummings JL. Neuropsychiatric symptoms in the dementias. Curr Opin Neurol. 2002 Aug;15(4):445-50. doi: 10.1097/00019052-200208000-00007. |
| 17329432 | Background | Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci. 2007 Feb 28;27(9):2349-56. doi: 10.1523/JNEUROSCI.5587-06.2007. |
| D019636 |
| Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D011596 | Psychomotor Disorders |
| D019954 | Neurobehavioral Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000096762 | Aberrant Motor Behavior in Dementia |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |