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The purpose of the study is to calculate magnitude, type of intraoperative brain shift and assess possibility of it's prediction.
Brain shift is the main natural cause of major navigation imprecision. Despite numerous attempts no trials showed a possibility to calculate and predict it's value although some patterns were found. Some modern navigational features allow to partially resolve this problem. Manual shift correction allows to displace brain structures but can only be used if brain shift is linear. Intraoperative computed tomography (CT) and magnetic resonance imaging (MRI) allow to update navigational data but violate surgical workflow and cannot display brain tissue in real time. Intraoperative sonography has poorer quality, limited observe volume and lengthy learning curve.
The purpose of the study is to calculate magnitude, type of intraoperative brain shift and assess possibility of it's prediction.
For each patient a surgeon intraoperatively will assess location of brain surface, various intracranial structures and lesion margins during surgery. Postoperatively these data will be compared to lesion's characteristics, patient's state and intraoperative features.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Surgery | Experimental | Removing different brain lesions using neuronavigation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Navigation-guided surgery | Device | Surgeon removes brain lesions and assesses brain shift with neuronavigation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Brain shift (in millimeters) | Maximal difference between disposition of different brain structures in preoperative scans and it's real intraoperative location | Intraoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Karnofsky Performance status in percents | Assesses patients' possibilities to self-service | within 10 days after surgery |
| Cerebral complications | Which cerebral complications arose after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alexander Dmitriev, MD | Contact | +7 (916) 423-54-08 | dmitriev@neurosklif.ru |
| Name | Affiliation | Role |
|---|---|---|
| Alexander Dmitriev, MD | Sklifosovsky Institute of Emergency Care | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sklifosovsky Institute of Emergency Care | Recruiting | Moscow | 129090 | Russia |
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| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| D018324 | Hemangioma, Capillary |
| D001165 | Arteriovenous Malformations |
| D002543 | Cerebral Hemorrhage |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D001927 | Brain Diseases |
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| ID | Term |
|---|---|
| D025321 | Surgery, Computer-Assisted |
| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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| From admission to intensive care unit after surgery till hospital discharge, up to 365 days |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006391 | Hemangioma |
| D009383 | Neoplasms, Vascular Tissue |
| D009370 | Neoplasms by Histologic Type |
| D054079 | Vascular Malformations |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |