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This study is to build a cohort of sudden sensorineural hearing loss (SSNHL) patients. When the patient visited the Department of otolaryngology clinic for hearing loss, we can diagnose the SSNHL following the result of pure tone audiometry and the history of the patient. The cohort is a system that tracks the hearing recovery status, timing, and degree of recovery of patients who received cocktail therapy with or without high-dose steroids, vasodilators, antiviral agents, and intratympanic steroid injections, satellite ganglion block, and hyperbaric oxygen therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SSNHL treated with WSCH protocol | SSNHL treated with WSCH protocol |
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| Measure | Description | Time Frame |
|---|---|---|
| Hearing outcome 1 week - PTA | Hearing change status near 1 weak after treatment start measured by pure tone audiometry1 | 1 week PTA |
| Hearing outcome 3 weeks - PTA | Hearing change status near 3 weaks after treatment start measured by pure tone audiometry | 3 weeks PTA |
| Hearing outcome 2 months - PTA | Hearing change status near 3 weaks after treatment start measured by pure tone audiometry | 2 month PTA |
| Hearing outcome 3 months - PTA | Hearing change status near 3 months after treatment start measured by pure tone audiometry | 3 month PTA |
| Hearing outcome 6 months - PTA | Hearing change status near 6 months after treatment start measured by pure tone audiometry, which is final. | 6 months PTA |
| Measure | Description | Time Frame |
|---|---|---|
| Electrolytes and chemistries after high dose steroid therapy | The results of blood tests of electrolytes and chemistries at 5 days after treatment start. (Na, K, Cl, CO2, BUN, Cr, Glucose, Amylase, Total protein, Albumin, AST, ALT, ALP, r-GT, Total Bilirubin) | 5 days electrolytes and chemistries |
| Measure | Description | Time Frame |
|---|---|---|
| Internal Acoustic canal MRI | The baseline studies of internal acoustic canal MRI results of SSNHL patients. | MRI |
Inclusion Criteria:
Exclusion Criteria:
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Among the adults over 20yrs of age, diagnosed sudden sensorineural hearing loss at Wonju Severance Christian Hospital, Department of otolaryngology.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tae Hoon Kong, MD, PhD | Contact | +821044650635 | cochlear84@yonsei.ac.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yonsei University Wonju Severance Christian Hospital | Recruiting | Wŏnju | Gangwon-do | 26426 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31369359 | Background | Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, Poling GL, Roberts JK, Stachler RJ, Zeitler DM, Corrigan MD, Nnacheta LC, Satterfield L. Clinical Practice Guideline: Sudden Hearing Loss (Update). Otolaryngol Head Neck Surg. 2019 Aug;161(1_suppl):S1-S45. doi: 10.1177/0194599819859885. | |
| 19283405 |
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| ID | Term |
|---|---|
| D003639 | Hearing Loss, Sudden |
| D034381 | Hearing Loss |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
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| Moon IS, Kim J, Lee SY, Choi HS, Lee WS. How long should the sudden hearing loss patients be followed after early steroid combination therapy? Eur Arch Otorhinolaryngol. 2009 Sep;266(9):1391-5. doi: 10.1007/s00405-009-0932-9. Epub 2009 Mar 13. |
| 22089956 | Background | Moon IS, Lee JD, Kim J, Hong SJ, Lee WS. Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss. Otol Neurotol. 2011 Dec;32(9):1432-6. doi: 10.1097/MAO.0b013e318238fc43. |
| 30267033 | Background | Rhee TM, Hwang D, Lee JS, Park J, Lee JM. Addition of Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. 2018 Dec 1;144(12):1153-1161. doi: 10.1001/jamaoto.2018.2133. |
| 27459199 | Background | Park SM, Han C, Lee JW, Kong TH, Seo YJ. Does Herpes Virus Reactivation Affect Prognosis in Idiopathic Sudden Sensorineural Hearing Loss? Clin Exp Otorhinolaryngol. 2017 Mar;10(1):66-70. doi: 10.21053/ceo.2016.00360. Epub 2016 Jul 27. |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |