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| ID | Type | Description | Link |
|---|---|---|---|
| R01AI143671 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| National Institute of Allergy and Infectious Diseases (NIAID) | NIH |
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A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays.
An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19.
The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cystic Fibrosis Carrier Group | Participants have been identified as Cystic Fibrosis Carriers via previous genetic testing. | ||
| Control Group | Participants have been identified as not being Cystic Fibrosis Carriers via previous genetic testing. |
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| Measure | Description | Time Frame |
|---|---|---|
| Comparison of Chloride Transport Values | Comparison of chloride transport values in cystic fibrosis carrier group vs control group via t-test. | At baseline |
| Comparison of Bicarbonate Transport Values | Comparison of bicarbonate transport values in cystic fibrosis carrier group vs control group via t-test. | At baseline |
| Comparison of Airway Surface Liquid pH Values | Comparison of airway surface liquid pH values in cystic fibrosis carrier group vs control group via t-test. | At baseline |
| Comparison of Mucous Viscosity Values | Comparison of mucous viscosity values in cystic fibrosis carrier group vs control group via t-test. | At baseline |
| Comparison of Bacterial Killing Values | Comparison of bacterial killing values in cystic fibrosis carrier group vs control group via t-test. | At baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of Fibroblast Growth Factor-19 Values | Comparison of fibroblast growth factor-19 values in cystic fibrosis carrier group vs control group via t-test. | At baseline |
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CF Carrier Inclusion Criteria:
Control Group Inclusion Criteria:
Exclusion Criteria:
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CF Carriers and Controls who are not CF carriers.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philip M Polgreen, MD | Contact | (319) 384-6194 | philip-polgreen@uiowa.edu | |
| Shelby L Francis, PhD | Contact | 319-678-8037 | shelby-francis@uiowa.edu |
| Name | Affiliation | Role |
|---|---|---|
| Philip M Polgreen, MD | University of Iowa | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Iowa Hospitals and Clinics | Recruiting | Iowa City | Iowa | 52242 | United States |
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| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| ID | Term |
|---|---|
| D007239 | Infections |
| D012140 | Respiratory Tract Diseases |
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Nasal cells and blood will be collected.