Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study mainly explored the relationship between the permeability of the blood-brain barrier in the dorsal medulla oblongata and autonomic dysfunction, and the relationship and mechanism of MAPT genotype on the permeability of the blood-brain barrier and the progression of autonomic dysfunction in PD patients.
According to the MDS 2015 clinical diagnostic criteria for Parkinson's disease and the diagnostic criteria for autonomic dysfunction (AutD), the patients were divided into PD with AutD group and PD without AutD group. DCE results, pet-pdrp+18f-dopa data and clinical evaluation (SCOPA-AUT, HRV and sleep EEG) were analyzed; Blood samples were collected to detect MAPT gene polymorphism, oligomers and phosphorylated synuclein. To explore the relationship between the permeability of the blood-brain barrier in the dorsal medulla oblongata and autonomic dysfunction, and the relationship and mechanism of MAPT genotype on the permeability of the blood-brain barrier and the progression of autonomic dysfunction in PD patients.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD with AutD | Parkinson's disease with autonomic dysfunction |
| |
| PD without AutD | Parkinson's disease without autonomic dysfunction |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autonomic dysfunction | Other | Autonomic dysfunction |
|
| Measure | Description | Time Frame |
|---|---|---|
| MAPT genotype | MAPT mainly has two extended haplotypes (H1 and H2) . | baseline |
| Dynamic changes of the permeability of blood-brain barrier in dorsal medulla oblongata | Dynamic contrast-enhanced MRI is used to measure the permeability of blood-brain barrier in dorsal medulla oblongata.Dynamic contrast ⁃ enhanced (DCE) ⁃ MRI is a very valuable quantitative MRI technology, which plays a great role in clinical research. Quantitative analysis can calculate the contrast agent concentration in the region of interest, and then improve the comparability of different research results. The permeability of blood-brain barrier is calculated by the volume transfer constant (Ktrans) between plasma and extravascular-extracellular space. | baseline,the sixth month,1year |
| Dynamic changes of SCOPA-AUT scale | The Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT) is used to evaluate autonomic nerve dysfunction. The SCOPA-AUT consists of 25 items assessing the following regions: gastrointestinal (7), urinary (6), cardiovascular (3), thermoregulatory (4), pupillomotor (1), and sexual (2 items for men and 2 items for women) dysfunction.Higher scores mean more severe autonomic dysfunction, with a minimum score of 0 and a maximum of 69. | baseline,the sixth month,1 year |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients with primary Parkinson's disease.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| shuzhen zhu, doctor | Contact | 86-020-783071 | 453951712@qq.com | |
| xiaoyan xu | Contact | 86-13829337718 | 914764405@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| shuzhen zhu, doctor | Southern Medical University, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhujiang Hospital of Southern Medical University | Recruiting | Guangzhou | Guangdong | 510000 | China |
Not provided
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D054969 | Primary Dysautonomias |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Microtubule associated protein tau (MAPT ) gene is located in 17q21.3 and contains 16 exons Due to the linkage disequilibrium inheritance of genes, MAPT mainly has two extended haplotypes (H1 and H2). This gene is responsible for encoding the neuronal microtubule associated protein tau, which is mainly distributed in the axons of neurons and plays an important role in the stability and assembly of microtubules. The gene polymorphism of MAPT is related to the clinical subtype of PD, in which MAPT H1J is related to sleep behavior disorder during rapid eye movement, while the risk of postural hypotension in H1B patients is increased by 1.72 times. The above studies suggest that the gene subtype of MAPT may be related to the occurrence and progression of early autd in PD patients.
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D001342 | Autonomic Nervous System Diseases |