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| Name | Class |
|---|---|
| First Affiliated Hospital, Sun Yat-Sen University | OTHER |
| ZHONGNANSHAN MEDICAL FOUNDATION OF GUANGDONG PROVINCE | UNKNOWN |
| Beijing Hospital | OTHER_GOV |
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Based on previous theoretical foundation and clinical practice experience, the investigators further propose a multi-center randomized prospective trial to compare the pure linear ablation strategy without pulmonary vein isolation to traditional PVI ablation for persistent AF. population size is 207. The participants will be randomized to the linear ablation group and PVI ablation group with a 2:1 ratio. the follow-up period is 12 months. The primary outcome is freedom from atrial fibrillation, the secondary outcome is complications related to ablation.
Pulmonary vein isolation is recommended as the cornerstone of catheter ablation of atrial fibrillation by current guidelines, However, meta-analysis suggests that the success rate of continuous pulmonary vein isolation for persistent atrial fibrillation is only 43%. Therefore, in addition to pulmonary vein isolation, further research on substrate modification in the treatment of atrial fibrillation is particularly important.
Based on our previous theoretical foundation and clinical practice experience, the investigators further propose a multi-center randomized prospective trial to compare the pure linear ablation strategy without pulmonary vein isolation to traditional PVI ablation for persistent AF. The linear ablation is performed on the basis of Ω-type linear ablation. Further stepwise ablation of the left atrial anterior wall increases the blockage of the LA roof and the MVA isthmus. Ablation in CS or ethanol ablation of vein of Marshall. Also, epicardial ablation on the roof or rigid between LAA-LPVs may be applied if necessary.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| linear ablation group | Experimental | The linear ablation is performed on the basis of Ω-type linear ablation. Further stepwise ablation of the left atrial anterior wall increases the blockage of the LA roof and the MVA isthmus. Ablation in CS or ethanol ablation of vein of Marshall. Also, epicardial ablation on the roof or rigid between LAA-LPVs may be applied if necessary. |
|
| PVI group | Other | pulmonary vein isolation ablation alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| catheter radiofrequency ablation(individualized stepwise linear without pulmonary vein isolation) | Procedure | individualized stepwise linear ablation without pulmonary vein isolation |
| Measure | Description | Time Frame |
|---|---|---|
| Freedom from atrial fibrillation at 1 year | Recurrent AF is defined as documented AF (through 12-lead ECG) episode lasting >30 seconds after a 3-month blanking period. | 12 months after the ablation |
| Measure | Description | Time Frame |
|---|---|---|
| complications related to ablation | Tamponade, pericarditis and perforation following the ablation procedure | 12 months after the ablation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College | Beijing | China |
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| Wuhan Asia Heart Hospital |
| OTHER |
| Tianjin Medical University General Hospital | OTHER |
| Fuwai Yunnan Cardiovascular Hospital | OTHER |
| RenJi Hospital | OTHER |
| Chinese Academy of Medical Sciences, Fuwai Hospital | OTHER |
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| catheter radiofrequency ablation(PVI) | Procedure | pulmonary vein isolation |
|
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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