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The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task.
A randomized, sham-controlled, between-subject design will be employed in this study. A total of 87 healthy subjects will receive either transcutaneous vagus nerve stimulation via tragus or sham stimulation via the earlobe in the left ear. Brain activity and behavioral data for an emotional Go-Nogo task will be recorded and saliva samples will be collected before, during, and after stimulation.
Some personal traits will be assessed using different kinds of questionnaires, such as the State-Trait Anxiety Inventory (STAI), Beck's Depression Inventory(BDI), Autism Spectrum Quotient (ASQ) et al.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tragus stimulation | Experimental | Vagus nerve stimulation via tragus |
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| Sham stimulation | Sham Comparator | Sham stimulation via earlobe |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vagus nerve stimulation via tragus | Device | The device will send stimulus intensity of around 0.5mA via tragus in the left ear (based on participants' subjective report), delivered with a pulse width of 0.5 ms at 25 Hz. Stimulation will be active for 30 seconds, followed by a break of 30 seconds. |
| Measure | Description | Time Frame |
|---|---|---|
| The ability of inhibitory control in an emotional Go-Nogo task | Analysis the behavioral and brain data recorded during the task | After 30 minutes stimulation |
| Oxytocin release | Investigating the oxytocin release after taVNS via tragus and earlobe based on saliva samples | within 5 minutes after taVNS via tragus and earlobe |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Electronic Science and Technology of China | Chengdu | Sichuan | 611731 | China |
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| Sham stimulation via earlobe | Device | The device will send stimulus intensity of around 0.5mA via the earlobe in the left ear (based on participants' subjective reports), delivered with a pulse width of 0.5 ms at 25 Hz. Stimulation will be active for 30 seconds, followed by a break of 30 seconds. |
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