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Randomized controlled trial of mixture of essential oils containing tea tree oil, rosemary, clove, pepper, in a formulation with skin permeation enhancers including limonene for the treatment of plantar fasciitis in adult men and women. Forty-two patients will be randomized to receive twice daily topical application of the treatment formulation or plain tea tree oil as a control. Analog pain scores will be assessed at the start of treatment and at two weeks. Analysis will be by student's T-test.
Randomized controlled trial of mixture of essential oils containing tea tree oil, rosemary, clove, pepper, in a formulation with skin permeation enhancers including limonene for the treatment of plantar fasciitis in adult men and women. Forty-two patients will be randomized to receive twice daily topical application of the treatment formulation or plain tea tree oil as a control. Analog pain scores will be assessed at the start of treatment and at two weeks. Analysis will be by student's T-test. Primary outcome measure will be the difference in pain score between baseline score and pain score at 2 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Plain Tea Tree Oil Control | Active Comparator | Topical application of 1ml 20% tea tree oil in almond oil base as a carrier twice daily for 2 weeks. |
|
| Verum | Experimental | Topical application twice daily of 1ml mixture for 2 weeks of essential oils containing tea tree oil, rosemary, clove, pepper, in a formulation with skin permeation enhancers including limonene. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topical oil application | Other | Topical Comparison |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pain Score Between Baseline and 2 Weeks | Patients will be asked to rate pain on a 1-10 analog scale at the start of the study and at 2 weeks | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Briant Burke, MD | Center for Biomedical Research, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Biomedical Research,Inc. | Boise | Idaho | 83706 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39085322 | Derived | Burke BE, Baillie JE. Randomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis. Sci Rep. 2024 Jul 31;14(1):17621. doi: 10.1038/s41598-024-65979-1. |
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| ID | Term |
|---|---|
| D036981 | Fasciitis, Plantar |
| D005208 | Fasciitis |
| ID | Term |
|---|---|
| D009140 | Musculoskeletal Diseases |
| D005534 | Foot Diseases |
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2 groups, plain tea tree oil control and formulated essential oil blend with permeation enhancer as treatment in a randomized trial
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Identical bottles given to participants with serial number, aroma and feel of each treatment group is the same