Multicenter Observational Study of PSC and IgG4-SC in China

Multicenter Study of Clinical Characteristics and Management of Primary Sclerosing Cholangitis and IgG4-related Sclerosing Cholangitis in China.

The investigators aimed to collect demographic features and clinical outcomes in patients diagnosed with PSC and IgG4-SC by utilizing participants database from multiple medical centers across Mainland China. Cross-sectional studies will focus on characterizing clinical presentations and validating diagnostic and prognostic models on Chinese PSC and IgG4-SC patients.

Inclusion Criteria:

• Age above 18 years old,
• Male or Female,
• Patients admitted in our medical centers which met the PSC criteria according to The European Association for the Study of the Liver Clinical Practice Guidelines "Management of cholestatic liver diseases" in 2009; or patients diagnosed with IgG4-SC which met initially using the Japan Pancreas Society criteria and confirmed using HISORt criteria.

Exclusion Criteria:

• Female subjects who is pregnant, breastfeeding or is considering being pregnant during the study;
• History of other malignancies, including hematological tumors, solid tumors except hepatobiliary system;
• History of infectious diseases, including hepatis A, B, C, E and tuberculosis.