For patients with initially unresectable colorectal liver metastasis (IU-CRLM) receiving effective conversion therapy, disease relapse after conversion hepatectomy is common due to the extensive tumor load. Yet, few studies have focused on the assessment and management of relapse after conversion hepatectomy for IU-CRLM. This study aimed to investigate the impact of surgical management for relapse after conversion hepatectomy in IU-CRLM.

Inclusion Criteria:

• initially unresectable colorectal liver metastasis (IU-CRLM)
• received conversion therapy
• underwent conversion hepatectomy

Exclusion Criteria:

• the histologic type of CRLM was not called adenocarcinoma
• uncontrollable extrahepatic metastases, such as peritoneal, bone, brain metastasis
• history of previous hepatectomy
• the primary tumor was not resected or palliative resection
• R1 or R2 liver resection

patients with initially unresectable colorectal liver metastasis (IU-CRLM) underwent hepatectomy after conversion therapy