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Synbiotic is a nutritional supplement that contains both prebiotic and probiotic. Probiotics are beneficial microorganisms, while prebiotics are foods that help the growth of beneficial microorganisms in the gut. In the study, dietary intervention with fruits and vegetables and/or synbiotic supplementation with be administered to Hong Kong Chinese subjects for eight weeks. Changes in the composition and diversity of intestinal microbiota, and markers indicative of obesity, chronic inflammation and metabolic dysfunction will be assessed throughout the whole period. This study will further provide a scientific basis for the intake of synbiotics for reducing the risk of overweight and obesity among Hong Kong Chinese. Furthermore, the results will bridge to further research into the most desirable gut microbiome profile, hence facilitating personalised nutrition for optimal health.
This is an 8-week randomized controlled dietary interventional trial.The objectives of this study include:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Synbiotic supplementation | Experimental | Synbiotic supplementation |
|
| Dietary intervention | Experimental | Dietary intervention |
|
| Synbiotic supplementation & dietary intervention | Experimental | Synbiotic supplementation & dietary intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Synbiotic supplementation | Dietary Supplement | Daily supplementation of synbiotic |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in body weight at week 8 compared with baseline | Body weight in kilogram | Week 0, 8 |
| Change in Body Mass Index (BMI) at week 8 compared with baseline | BMI = Body weight (in kilograms) divided by square of body height (in meters) | Week 0, 8 |
| Change in body fat percentage at week 8 compared with baseline | Body fat percentage is assessed by bioimpedence | Week 0, 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in fasting glucose at week 8 compared with baseline | Fasting glucose in mmol/L | Week 0, 8 |
| Change in fasting insulin at week 8 compared with baseline | Fasting insulin in pmol/L |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hoi Shan Kwan, PhD | Chinese University of Hong Kong | Study Chair |
| Peter Chi Keung Cheung, PhD | Chinese University of Hong Kong | Study Director |
| Susana Lauw, MSc | Chinese University of Hong Kong | Principal Investigator |
| Nelson Kei, BSc | Chinese University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Chinese University of Hong Kong | Shatin | 000000 | Hong Kong |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| ID | Term |
|---|---|
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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| Dietary intervention | Behavioral | Increased fruits and vegetables consumption |
|
| Week 0, 8 |
| Changes in fasting lipids at week 8 compared with baseline |
| Week 0, 8 |
| Use of 16S rRNA gene sequencing to assess the changes in the composition of the gut microbiota (bacteriome) of stool samples at week 8 compared with baseline | The composition of the gut microbiota (bacteriome) of stool samples is assessed by 16S rRNA gene sequencing | Week 0, 8 |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |