Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Qianfoshan Hospital | OTHER |
| The Second Hospital of Shandong University | OTHER |
| The Affiliated Hospital of Qingdao University | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose is to study the population pharmacokinetics, effectiveness and safety of antiepileptic drug (phenytoin, carbamazepine, lamotrigine, levetiracetam, parempanel, etc) in elderly patients and recommend optimized dosage regimens.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | The use of antiepileptic drugs depends on the clinical practice. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| antiepileptic drugs | Drug | phenytoin, carbamazepine, lamotrigine, levetiracetam, perampanel, etc. as part of routine treatment. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The peak plasma drug concentration of antiepileptic drugs. | To detect the peak plasma drug concentration of antiepileptic drugs. | at (0-4) h after oral administration |
| The random plasma drug concentration of antiepileptic drugs. | To detect the random plasma drug concentration of antiepileptic drugs. | at (4-10) h after oral administration |
| The trough plasma drug concentration of antiepileptic drugs. | To detect the trough plasma drug concentration of antiepileptic drugs. | at (1-2) h before the next administration |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of adverse drug reaction | Through study completion, an average of 14 days | |
| The frequency of seizures | Through study completion, an average of 14 days |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Elderly patients with epilepsy (≥65years).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wei Zhao | Contact | 86053188383308 | zhao4wei2@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Wei Zhao | Qianfoshan Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wei Zhao | Recruiting | Jinan | Shandong | China |
Not provided
| ID | Term |
|---|---|
| D012640 | Seizures |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D000927 | Anticonvulsants |
| ID | Term |
|---|---|
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
Not provided
Not provided
Not provided
Not provided
Not provided