The Flapless Approach in Periodontal Regeneration

The Flapless Approach With and Without Enamel Matrix Derivatives in the Regenerative Treatment of Intrabony Defects: a Randomized Controlled Clinical Trial

The present investigation is designed in order to compare the radiographic and clinical effectiveness of flapless procedure performed alone or in combination with enamel matrix derivatives in the periodontal regenerative treatment of deep intrabony defects in patients with moderate or severe periodontitis. The study will have a follow-up of 12 months.

Inclusion Criteria:

• diagnosis of periodontitis stage III or IV;
• presence of at least one tooth with ≥6 mm associated with a radiographic intrabony defect ≥3 mm at least 2 months after the completion of non-surgical therapy;
• a full-mouth plaque score and full-mouth bleeding score <15% at the time of the experimental procedure;
• signed informed consent.

Exclusion Criteria:

• relevant medical disorders contraindicating periodontal surgery or detrimental to periodontal healing;
• consumption of drugs known to affect periodontal status;
• pregnancy and lactation;
• third molars, teeth with furcation involvement or inadequate endodontic treatment and/or prosthetic restoration;
• heavy smokers >10 cigarettes per day.