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Background The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of Health and Development (NSHD) is the world's longest running continued surveillance birth cohort providing a unique opportunity to understand life course determinants of myocardial dysfunction as part of MyoFit46-the cardiac sub-study of the NSHD.
Methods and expected results The investigators aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR). Through comprehensive myocardial tissue characterization and 4-dimensional flow the investigators hope to better understand the burden of clinical and subclinical cardiovascular disease. Supercomputers will be used to combine the multi-scale ECGI and CMR datasets per participant. Rarely available, prospectively collected whole-of-life data on exposures, traditional risk factors and multimorbidity will be studied to identify risk trajectories, critical change periods, mediators and cumulative impacts on the myocardium.
Conclusion By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR-ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to transform our understanding of how early, mid and later-life risk factor trajectories interact to determine the state of cardiovascular health in older age.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CMR CGI | Diagnostic Test | High resolution ECGI plus advanced CMR |
| Measure | Description | Time Frame |
|---|---|---|
| CMR phenotype - T1 | This will be assessed through a 45 minute cardiac MRI scan with perfusion. | Through study completion, an average of 4 years. |
| CMR phenotype - T2 | This will be assessed through a 45 minute cardiac MRI scan with perfusion. | Through study completion, an average of 4 years. |
| CMR phenotype - Myocardial blood flow | This will be assessed through a 45 minute cardiac MRI scan with perfusion. | Through study completion, an average of 4 years. |
| CMR phenotype - Aortic blood flow | This will be assessed through a 45 minute cardiac MRI scan with perfusion. | Through study completion, an average of 4 years. |
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Inclusion Criteria:
Exclusion Criteria:
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NSHD cohort
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gabriella Captur, MD PhD MSc MRCP | Contact | +447809621264 | gabycaptur@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCL Bloomsbury Centre for Clinical Phenotyping | Recruiting | London | SW13 0JD | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41796595 | Derived | Webber M, Chan F, Topriceanu CC, Martin E, Joy G, Bennett J, Falconer D, Morselli F, Shiwani H, Gonzalez P, Hamill Howes L, Wong A, Rapala A, Bandula S, Davies RH, Kellman P, Pierce I, Orini M, Hardy R, Chaturvedi N, Moon JC, Lambiase PD, Hughes AD, Captur G. Incidental findings and duty-of-care protocols in cardiovascular magnetic resonance among older adults: a prospective population-based study from MyoFit46. Lancet Healthy Longev. 2026 Feb;7(2):100823. doi: 10.1016/j.lanhl.2026.100823. Epub 2026 Mar 5. | |
| 41404671 |
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Non-identifiable data sharing to external collaborators. Additional data sharing available within UCL TRE.
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Derived |
| Topriceanu CC, Webber M, Shiwani H, Chan F, Martin E, Falconer D, Stanley MA, Bennett J, Gonzalez-Martin P, Shah H, De S, Wong A, Pierce I, Davies RH, Lambiase PD, Chaturvedi N, Kellman P, Hardy R, Moon JC, Hughes AD, Captur G. Higher Life-Course Blood Pressure Associates With Reduced Myocardial Perfusion in Older Age: Insights From MyoFit46. Circ Cardiovasc Imaging. 2026 Feb;19(2):e019105. doi: 10.1161/CIRCIMAGING.125.019105. Epub 2025 Nov 8. |
| 38044439 | Derived | Webber M, Joy G, Bennett J, Chan F, Falconer D, Shiwani H, Davies RH, Krausz G, Tanackovic S, Guger C, Gonzalez P, Martin E, Wong A, Rapala A, Direk K, Kellman P, Pierce I, Rudy Y, Vijayakumar R, Chaturvedi N, Hughes AD, Moon JC, Lambiase PD, Tao X, Koncar V, Orini M, Captur G. Technical development and feasibility of a reusable vest to integrate cardiovascular magnetic resonance with electrocardiographic imaging. J Cardiovasc Magn Reson. 2023 Dec 4;25(1):73. doi: 10.1186/s12968-023-00980-7. |