Perioperative Blood Glucose Variability and Autonomic Nervous System Activity in On-pump Cardiac Surgery Patients: Study Protocol of a Single-center Observational Study.
Perioperative Blood Glucose Variability and Autonomic Nervous System Activity in On-pump Cardiac Surgery Patients: Study Protocol of a Single-center Observational Study.
On-pump coronary artery bypass graft (CABG) and valve replacement surgeries are high-risk procedures. Among the risk factors for postoperative complications, perioperative hyperglycemia and blood glucose variability have been reported to be associated with increased morbidity and mortality. The treatment of hyperglycemia using intravenous insulin infusion improves the prognosis in cardiac surgery patients. However, the determinants of postoperative blood glucose variability and the mechanisms leading to its deleterious impact are unknown. Thus, to date, there is no therapeutic intervention that could effectively prevent and treat the deleterious impact of glycemic variability on postoperative outcome. The purpose of the study is to evaluate whether perioperative alteration of the autonomic nervous system and preoperative blood glucose variability could be related to perioperative glycemic variability.
The main objective is to describe the relationship between preoperative glycemic variability and glycemic variability during the first 48 postoperative hours.
The secondary objectives are :
to describe the relationship between preoperative glycemic variability and glycemic variability during the first 48 hours postoperative according to:
to describe the relationship between the parameters evaluating the preoperative activity of the autonomic nervous system and:
to describe the relationship between glycemic variability during the first 48 postoperative hours and:
to describe the morbidity and mortality within 30 days after surgery.
Inclusion Criteria:
Exclusion Criteria: