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| Name | Class |
|---|---|
| KaiLuan General Hospital | OTHER |
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The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| subjects from Kailuan community | 1. Age from 18 to 90 years old; 2. Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured; 3. Without contraindications of CT and MR scan; 4. Can cooperate with the measurement of the medical history, physiological indicators and brain imaging. Subjects with the following conditions should be excluded: 1. Known clinical history with congenital or acquired organic diseases (such as aortic stenosis); 2. Known history of drug abuse; 3. Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention will be applied. | Other | This is an observational study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years | |
| microbleeds of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years | |
| Lacunes of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years | |
| Cerebral blood flow measured by MRI (magnetic resonance imaging) | every two years up to 30 years | |
| Brain volume measured by MRI (magnetic resonance imaging) | every two years up to 30 years | |
| White matter microstructural integrity of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years |
| Measure | Description | Time Frame |
|---|---|---|
| blood glucose level | every two years up to 30 years | |
| Cervical vascular ultrasound | every two years up to 30 years | |
| Fundus color photography of the eyes |
| Measure | Description | Time Frame |
|---|---|---|
| Pulse Wave Velocity, PWV | every two years up to 30 years | |
| Lipoprotein | every two years up to 30 years |
Inclusion Criteria:
Exclusion Criteria:
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Subjects from Kailuan Cohorts
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhenchang Wang | Contact | +86-13501163497 | cjr.wzhch@vip.163.com | |
| Jing Li | Contact | +86-13693544716 | lijingxbhtr@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Friendship Hospital, Capital Medical University | Not yet recruiting | Beijing | Beijing Municipality | 100050 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42230333 | Derived | Sun J, Hui Y, Li J, Zhao X, Zhao P, Li X, Chen S, Wu S, Wang Z, Lv H. Association of long-term exposure to lower low-density lipoprotein cholesterol with neuroimaging metrics: A population-based cohort study. Chin Med J (Engl). 2026 Jun 2. doi: 10.1097/CM9.0000000000004105. Online ahead of print. | |
| 41106763 | Derived |
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| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| every two years up to 30 years |
| Fundus optical coherence tomography (OCT) | every two years up to 30 years |
| Blood pressure (both Systolic and Diastolic Blood Pressure) | every two years up to 30 years |
| BMI (body mass index) | every two years up to 30 years |
| Uric acid | every two years up to 30 years |
| Kailuan General Hospital | Recruiting | Tangshan | Hebei | 063000 | China |
|
| Guo S, Sun J, Zhang Y, Li X, Li J, Zhao X, Zhao P, Chen S, Wu S, Hui Y, Wang Z, Lv H. Association of long-term blood pressure exposure with DTI-ALPS: A population-based cohort study. Brain Res. 2025 Dec 1;1868:149998. doi: 10.1016/j.brainres.2025.149998. Epub 2025 Oct 15. |
| 40770361 | Derived | Tong N, Hui Y, Gou SP, Chen LX, Wang XH, Chen SH, Li J, Li XS, Wu YT, Wu SL, Wang ZC, Sun J, Lv H. Clinical information prompt-driven retinal fundus image for brain health evaluation. Mil Med Res. 2025 Aug 6;12(1):47. doi: 10.1186/s40779-025-00630-2. |
| 39549242 | Derived | Zhao X, Hui Y, Li J, Shi XQ, Chen S, Lv H, Wu S, Wang Z. Higher Long-Term Visit-to-Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population. J Clin Hypertens (Greenwich). 2025 Jan;27(1):e14943. doi: 10.1111/jch.14943. Epub 2024 Nov 16. |
| 38580007 | Derived | Zhang T, Lv H, Zhao X, Zeng N, Hui Y, Chen S, Wu N, Xu M, Wu Y, Xing A, Shi H, Zhang S, Liang X, Wang Y, Wu S, Cui L, Wang Z, Liu Y. Serum uric acid is associated with midbrain enlarged perivascular spaces: Results from Multi-modality Medical imaging sTudy bAsed on KaiLuan Study (META-KLS). Prog Neuropsychopharmacol Biol Psychiatry. 2024 Jul 13;133:111000. doi: 10.1016/j.pnpbp.2024.111000. Epub 2024 Apr 3. |
| 38500551 | Derived | Lv H, Zeng N, Li M, Sun J, Wu N, Xu M, Chen Q, Zhao X, Chen S, Liu W, Li X, Zhao P, Wintermark M, Hui Y, Li J, Wu S, Wang Z. Association between Body Mass Index and Brain Health in Adults: A 16-Year Population-Based Cohort and Mendelian Randomization Study. Health Data Sci. 2024 Mar 15;4:0087. doi: 10.34133/hds.0087. eCollection 2024. |
| 36764715 | Derived | Sun J, Hui Y, Li J, Zhao X, Chen Q, Li X, Wu N, Xu M, Liu W, Li R, Zhao P, Wu Y, Xing A, Shi H, Zhang S, Liang X, Wang Y, Lv H, Wu S, Wang Z. Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building. BMJ Open. 2023 Feb 10;13(2):e067283. doi: 10.1136/bmjopen-2022-067283. |