Medication Adherence Monitoring Trial Using Smart Clinical Trial Application and Smart Watch

An Open, Randomized and Parallel-design Exploratory Clinical Trial to Evaluate the Effect of Smart Medication Adherence Monitoring on the Medication Adherence and Blood Vitamin D Concentration

The study will investigate the effect of smart monitoring on medication adherence.

In this study, multiple medication monitoring procedures will be performed: self-reporting, pill counting, smart monitoring and concentration monitoring. Subjects will take vitamin D supplement on the market which enables validated concentration monitoring. The study will last for 3 months.

Inclusion Criteria:

• Adults aged 19-64 years at the consent
• 25(OH) vitamin D < 10 ng/mL
• Not taking vitamin D at the screening
• Fully understood the study procedures

Exclusion Criteria:

• Hypercalciuria, sarcoidosis

• Clinically significant hypersensitivity reaction to Vitamin D

• History of or current kidney stone

• One of the following findings:

  1. Serum calcium level > upper limit of normal
  2. Estimated glomerular filtration rate < 60 mL/min/1.73m^2

• Galactose intolerance, Lapp lactase deficiency, Glucose-galactose malabsorption

• Unable to use smart clinical trial application or smart watch

• Expected to take vitamin D from 4 weeks before the first administration and until the last administration