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| Name | Class |
|---|---|
| Peking Union Medical College Hospital | OTHER |
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The investigators will retrospectively analyze the clinical data of consecutive patients with pheochromocytomas and paragangliomas admitted between January 2018 and June 2020. The clinical characteristics of patients with and without dysglycemia will be compared, and whether surgery could improve the patients'dysglycemia will be also investigated.
This retrospective cohort study will include all consecutive adult patients who underwent surgery for PHEOs and catecholamine-secreting PGLs from January 2018 to June 2020. Patients with recurrent PPGLs, those who required steroids after adrenalectomy, and those with inadequate clinical records were excluded. The patients' electronic medical files were reviewed. Patients with dysglycemia included those with diabetes, or impaired fasting glucose, or impaired glucose tolerance. Clinical history data such as age, sex, body mass index (BMI), the presence of preoperative symptoms, biochemical test results, and tumor characteristics, such as tumor diameters and locations were extracted and analyzed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with dysglycemia | Patients with dysglycemia in the included subjects with pheochromocytoma and paraganglioma |
| |
| patients without dysglycemia | Patients without dysglycemia in the included subjects with pheochromocytoma and paraganglioma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Catecholamines | Other | Focus on whether catecholamine exposure is associated with dysglycemia in patients with pheochromocytoma and paraganglioma |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline OGTT（oral glucose tolerance test）results to 6-12 months after surgery | OGTT results （including fasting blood glucose in the text, blood glucose results at 2 hours after oral administration of 75g glucose）at baseline and 6-12 months after surgery will be recorded to assess the effect of surgery on dysglycemia | Baseline, 6-12 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| random blood glucose results | random blood glucose results at baseline and 6-12 months after surgery will be recorded to assess the effect of surgery on dysglycemia | baseline, 6-12 months after surgery |
| HbA1c |
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Inclusion Criteria:
Exclusion Criteria:
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This retrospective cohort study will include all consecutive adult patients who underwent surgery for pheochromocytomas and paragangliomas from January 2018 to June 2020.
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| Name | Affiliation | Role |
|---|---|---|
| Xian-Liang Zhou | National Center for Cardiovascular Diseases; Fuwai Hospital, Chinese Academy of Medical Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xian-Liang Zhou | Beijing | Beijing Municipality | 100037 | China |
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| ID | Term |
|---|---|
| D010673 | Pheochromocytoma |
| D010235 | Paraganglioma |
| ID | Term |
|---|---|
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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| ID | Term |
|---|---|
| D002395 | Catecholamines |
| ID | Term |
|---|---|
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 |
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HbA1c results at baseline and 6-12 months after surgery will be recorded to assess the effect of surgery on dysglycemia
| baseline, 6-12 months after surgery |
| fasting blood glucose | fasting blood glucose results at baseline and 6-12 months after surgery will be recorded to assess the effect of surgery on dysglycemia | baseline, 6-12 months after surgery |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |