Association Between the Results of Specific Genetic Tests and the Efficacy of Targeted Therapies in Patients

Clinical Trials to Evaluate the Association Between the Results of Specific Genetic Tests and the Efficacy of Targeted Therapies in Patients With Non-small Cell Lung Cancer

Our study aimed to evaluate the correlation between test reagent specific gene test results and the efficacy of relevant targeted drugs in patients with non-small cell lung cancer, and to support the continued registration of test reagents.

Inclusion Criteria:

• 1)≥18，advanced non-small cell lung cancer confirmed by histopathology, and were previously or currently treated with gefitinib tablets (as the first-line treatment) or osimertinib (first-generation TKI resistance treatment) or crizotinib capsules monotherapy were evaluated for efficacy.
• 2) Able to provide FFPE samples with a storage life of 5 years: Large specimen 5 pieces in each case; 10 puncture specimens in each case

Exclusion Criteria:

• 1) Pathological evaluation of the tissue sample has too few tumor cells (total number of tumor cells >20%);
• 2) Combination therapy with chemotherapy/radiotherapy/other targeted drugs/immunotherapy drugs;
• 3) Maintenance treatment when the disease does not progress after other anti-tumor treatments.