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This is a prospective, randomized, controlled trial for evaluating the efficacy of addition of transversus thoracic muscle plane block to pectoral nerves block versus pectoral nerves block for quality of recovery scores in breast cancer surgery.
The pectoral nerves (PECS) block cannot block the most internal mammary region, whereas a transversus thoracic muscle plane (TTP) block can. The combination of PECS and TTP blocks may be suitable for breast cancer surgery. We studied patients undergoing breast cancer surgery to assess whether the combination of PECS and TTP blocks provides better postoperative recovery than PECS block alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| transversus thoracic muscle plane block+pectoral nerves block | Experimental | the combination of transversus thoracic muscle plane and pectoral nerves blocks |
|
| pectoral nerves block | Active Comparator | the pectoral nerves block only |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| the combination of transversus thoracic muscle plane and pectoral nerves blocks | Procedure | For the pectoral nerves block, 0.375% ropivacaine , 10ml was injected between the pectoralis major and pectoralis minor and 20 ml above the serratus anterior muscle. For the transversus thoracic muscle plane block, ropivacaine 0.375%,15ml was injected between the transversus thoracic muscle and the internal intercostal muscle. |
| Measure | Description | Time Frame |
|---|---|---|
| the quality of recovery-15 questionnaire (QoR-15) | The QoR-15 is a validated short-form postoperative quality of recovery score. Fifteen questions assess five domains of patient health-related quality of life: pain; comfort; physical independence; psychological support; and emotional state. Each question uses an 11-point rating scale, in which the maximum score is 150, denoting excellent recovery.
| at 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| NRS score for rest and coughing pain | Postoperative pain at rest and during coughing was assessed by NRS score with a range of 0 to 10 (0=no pain, 10=the worst possible pain) | at 1, 6, 24, 48 hours after surgery |
| consumption of opioid converted to IV morphine equivalents |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Huifang Jiang, MD | Zhejiang Cancer Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhejiang Cancer Hospital | Hangzhou | Zhejiang | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39453840 | Derived | Gu B, Huang ZX, Zhou HD, Lian YH, He S, Ge M, Jiang HF. A Randomized Controlled Trial of Adding Deep Parasternal Intercostal Plane Block to Interpectoral-Pectoserratus Plane Block in Breast Cancer Surgery. Anesth Analg. 2025 May 1;140(5):1188-1194. doi: 10.1213/ANE.0000000000007218. |
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Yes: There is a plan to make IPD and related data dictionaries available.
starting about 6 months after publication
We will share data on ClinicalTrials.gov, and data sharing will be always available.
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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|
| the pectoral nerves block only | Procedure | For the pectoral nerves block, 0.375% ropivacaine , 10ml was injected between the pectoralis major and pectoralis minor and 20 ml above the serratus anterior muscle. |
|
opioids given postoperatively converted to IV morphine equivalents |
| during 24 hours after surgery |
| the incidence of postoperative hypotension | Adverse reactions related to opioid | during 48 hours after surgery |
| the incidence of nausea and vomiting | Adverse reactions related to opioid | during 48 hours after surgery |
| the incidence of pruritus | Adverse reactions related to opioid | during 48 hours after surgery |
| the incidence of respiratory depression | Adverse reactions related to opioid | during 48 hours after surgery |
| time to urethral catheter removal in hours | Time tourethral catheter removal after surgery | through study completion, an average of 24-36 hours |
| postoperative hospital stay in days | The time from operation to discharge | through study completion, an average of 5-7 days |
| intra-operative opioid requirements | opioids given intra-operatively | through the anesthesia process, an average of 1.5-2.5h |
| the block-related outcomes | the incidence of block-related complications (accidental intravascular injection, local anaesthetic systemic toxicity, haematoma and pneumothorax); and incidence of patient-reported transient neurological complications (paraesthesia or sensory deficit) | through study completion, an average of 5-7 days |
| the Brief Pain Inventory | The Brief Pain Inventory instrument assesses 2 domains: pain and pain-related interference with physical and emotional functioning.
| at 3 months after surgery. |
| D017437 |
| Skin and Connective Tissue Diseases |