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The NEURESCUE device is the first intelligent catheter for aortic balloon occlusion, an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment.
The catheter-based device is delivered via the femoral artery, temporarily inflating a soft balloon in the descending aorta to redirect blood flow towards the upper body.
The objective of this study is to investigate the feasibility of the NEURESCUE device as an adjunct to Advanced Cardiac Life Support (ACLS) in adults with cardiac arrest.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Experimental | The NEURESCUE device will be used as an adjunct to ACLS. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NEURESCUE device | Device | The balloon catheter is delivered via the femoral artery, temporarily inflating a soft balloon in the descending aorta to redirect blood flow towards the upper body. |
| Measure | Description | Time Frame |
|---|---|---|
| Successful balloon inflation within 10 minutes from first vessel puncture | Assessed up to 10 min |
| Measure | Description | Time Frame |
|---|---|---|
| Change in central blood pressure | Assessed up to 1 hour | |
| Total ACLS time at initiation of the investigational procedure | Assessed up to 1 hour | |
| Time from first vessel puncture to successful sheath insertion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David Shavelle, M.D. | Long Beach Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Long Beach Medical Center | Long Beach | California | 90806 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41237845 | Derived | Rusnak J, Thevathasan T, Skurk C, Zelniker TA, Frost H, Eden M, Speer C, Frey N, Preusch MR. Feasibility of computer-aided aortic occlusion catheter in non-traumatic cardiac arrest. Resuscitation. 2025 Dec;217:110879. doi: 10.1016/j.resuscitation.2025.110879. Epub 2025 Nov 12. |
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Individual request
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
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| Assessed up to 1 hour |
| Rate of occlusion success | Assessed up to 1 hour |
| Return of spontaneous circulation (ROSC) | The endpoint is dichotomous (yes/no) for each subject | Assessed up to 1 hour |