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AFHRI is planned as a prospective, single-center cohort study in patients at high risk of AF.
The primary aim of the study is to evaluate and improve atrial fibrillation risk prediction, which takes into account clinical, psycho-social, environmental and lifestyle-risk factors, protein patterns and genetic variability in addition to the classical risk factors with respect to the primary endpoint, AF (paroxysmal or permanent).
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| Measure | Description | Time Frame |
|---|---|---|
| Incident atrial fibrillation | 12-lead Electrocardiogram (ECG) tracing, diagnosis of AF will be made if at least two cardiologists verify the rhythm abnormality using clinic visit, outside physician or hospital records, or ambulatory ECG reports. | up to 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial infarction | Typical rise and gradual fall (Troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis | up to 4 years |
| Cardiovascular death | if no other underlying cause of death is diagnosed: hypertension, coronary heart disease, other cardiovascular disease, atherosclerosis, diabetes mellitus, dyslipidemia, obesity, sudden death and cardiac symptoms |
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Inclusion Criteria:
Exclusion Criteria:
1/1 selection
Outpatient cardiology sample at risk for AF. Recruitment in a single center design, at the Department of Cardiology, University Medical Center Hamburg-Eppendorf.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Renate B Schnabel, Prof. | Contact | r.schnabel@uke.de | ||
| Daniel Engler, MSc. | Contact | d.engler@uke.de |
| Name | Affiliation | Role |
|---|---|---|
| Renate B Schnabel, Prof. | Department of Cardiology, University Medical Center Hamburg-Eppendorf | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiology, University Medical Center Hamburg-Eppendorf | Recruiting | Hamburg | 20246 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35064145 | Result | Assum I, Krause J, Scheinhardt MO, Muller C, Hammer E, Borschel CS, Volker U, Conradi L, Geelhoed B, Zeller T, Schnabel RB, Heinig M. Tissue-specific multi-omics analysis of atrial fibrillation. Nat Commun. 2022 Jan 21;13(1):441. doi: 10.1038/s41467-022-27953-1. |
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Owing to propriety nature, supporting data cannot be made available openly. Further information about the data and access conditions is available uppon request
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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sophisticated biobank including DNA, RNA, cells, and serum/plasma for comprehensive genetic, gene expression and proteomic studies
| up to 4 years |
| Heart failure | echocardiography including Doppler-flow measurement | up to 4 years |
| D013568 |
| Pathological Conditions, Signs and Symptoms |