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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-A01928-33 | Other Identifier | France : Ministry of Health |
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| Name | Class |
|---|---|
| URC-CIC Paris Descartes Necker Cochin | OTHER |
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The purpose of this study is to describe and compare the kinematic deficiencies specifically associated with each of the 3 main clinical phenotypes of patellofemoral pain syndrome. The prevalence of patellofemoral pain is high with a high rate of chronicity and recurrence and an overrepresentation of young, athletic and female populations. There are multiple classifications of patellofemoral pain syndrome. A pragmatic classification distinguishes 3 main clinical phenotypes of patellofemoral pain syndrome: with objectively displaceable patella, with extra-patellar alignment problems and without alignment problems.
The pathophysiology of patellofemoral pain syndrome is multifactorial involving static and dynamic dysfunctions of the hip, knee and foot, which remain incompletely elucidated to date. The links between the clinical and biomechanical aspects are still unclear and the kinematic and neuromuscular deficiencies associated with the 3 main clinical phenotypes are poorly understood. A validated non-invasive device allows the 3D evaluation of femorotibial rotations during walking.
The diagnostic process is based on clinical examination. The evolution of measuring tools like radios, RMI and kinematics device allows a more precise diagnostic of patellofemoral Pain syndrome. We still don't know what kind of gait parameters could help to categorize the different phenotypes. With a better understanding of these phenotypes the investigators will be able to propose a better personalized rehabilitation.
Patellofemoral pain syndrome is defined as an anterior knee pain in front of and around the patella. The diagnosis of patellofemoral pain syndrome is based on clinical examination and standard imaging.
The pathophysiology of the patellofemoral pain syndrome is multifactorial involving static and dynamic dysfunctions of the hip, knee and foot, which remain incompletely elucidated to date. The prevalence of patellofemoral pain is high with a high rate of chronicity and recurrence and an overrepresentation of young, athletic and female populations. A pragmatic classification distinguishes 3 main clinical phenotypes of patellofemoral pain syndrome: with objectively displaceable patella, with extra-patellar alignment problems and without alignment problems.
The links between the clinic and biomechanics are still unclear and the kinematics and neuromuscular impairments associated with the 3 main clinical phenotypes are poorly understood.
The KneeKG is an optoelectronic kinematic assessment device using non-invasive sensors and dedicated to real-time measurement of 3D femoro-tibial position and rotations. The kinematic, neuro-muscular, postural and proprioceptive assessments will allow us to better understand the pathophysiology of the patellofemoral pain syndrome, to establish a more accurate diagnosis of the disease, and provide a better understanding of its causes.
Several studies have shown that better adherence to exercise is associated with greater benefit in terms of pain and function in chronic pathologies.
Semi-structured interviews will enable the investigators to assess the impact of information derived from kinematic examination of the knees on adherence to treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patellofemoral pain syndrome | Experimental | Kinematic and neuromuscular assessment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EOS Radiation | Other | One EOS exam of lower extremities |
|
| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of rotation | Amplitude of rotation of the femur with respect to the tibia in the bearing phase in the 3 planes of space | Day of inclusion (up to 10 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Length measures | EOS femoro-tibial alignment | Day of inclusion (up to 10 days) |
| Q angle (in degree) | EOS femoro-tibial alignment | Day of inclusion (up to 10 days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marvin COLEMAN, MSc, PhD student | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis - Hôpital Cochin | Paris | Île-de-France Region | 75014 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42001620 | Result | Coleman M, Gizolme L, Hagemeister N, Nguyen C, Rannou F, Dietrich G, Lefevre-Colau MM, Roren A. 3D kinematic knee variables in people with unilateral patellofemoral pain syndrome: comparison of symptomatic and contralateral knees. Ann Phys Rehabil Med. 2026 Jun;69(5):102124. doi: 10.1016/j.rehab.2026.102124. Epub 2026 Apr 18. No abstract available. |
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| ID | Term |
|---|---|
| D046788 | Patellofemoral Pain Syndrome |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Semi-structured interview | Behavioral | Semi-structured interview to identify factors influencing patient adherence behavior for a sub-group of 15 patients. By phone, between 1 to 3 months after inclusion. |
|
| Varus valgus(in degree) | EOS femoro-tibial alignment | Day of inclusion (up to 10 days) |
| Peak torque (N.m) | Quadriceps isokinetic strenght | Day of inclusion (up to 10 days) |
| Total work (N.m) | Quadriceps isokinetic strenght | Day of inclusion (up to 10 days) |
| Peak torque (N.m) | Hamstrings isokinetic strenght | Day of inclusion (up to 10 days) |
| Total work (N.m) | Hamstrings isokinetic strenght | Day of inclusion (up to 10 days) |
| Quadriceps/Hamstring ratio : 2 measure/leg | Day of inclusion (up to 10 days) |
| Peak torque (N.m) | Hip abductors static strenght | Day of inclusion (up to 10 days) |
| Average torque (N.m) | Hip abductors static strenght | Day of inclusion (up to 10 days) |
| Time for reaching peak (s) | Hip abductors static strenght | Day of inclusion (up to 10 days) |
| Time difference in the onset between the m.vastus lateralis and m.vastus medialis contraction in ms | Activity of the quadriceps measured. Electromyogram was used to quantify the electric potential of quadriceps and referred to as 'quadriceps muscle EMG activity' throughout | Day of inclusion (up to 10 days) |
| Y test | Static and dynamic unipodal balance | Day of inclusion (up to 10 days) |
| Eccentric step-down test | Static and dynamic unipodal balance | Day of inclusion (up to 10 days) |
| Lateral step down test | Static and dynamic unipodal balance | Day of inclusion (up to 10 days) |
| Unipodal stabilometric evaluation | Static and dynamic unipodal balance | Day of inclusion (up to 10 days) |
| Foot posture index | Foot static | Day of inclusion (up to 10 days) |
| Navicular drop test | Foot static | Day of inclusion (up to 10 days) |
| Ober's test | Muscle hypoextensibility. Quadriceps, harmstrings, calves, | Day of inclusion (up to 10 days) |
| Visual Analog Scale | Determine pain / No pain = 0, maximal pain =100 | Day of inclusion (up to 10 days) |
| Anterior knee pain scale (AKPS) | Questionnaire to determine pain / 13 questions, minimum score = 0 point, maximum score = 100 points | Day of inclusion (up to 10 days) |
| 12-Item Short Form Survey (SF-12) | Quality of life, to determine pain | Day of inclusion (up to 10 days) |
| Semi-structured interview | Semi-structured interview for a sub-group of 15 patients identify factors influencing patient adherence behavior. | From month 1 to month 3 |